替米沙坦片中含量检测方案(液相色谱柱)

HPLCDATA：SHEET 于儿三廿儿夕沙锭(日本藥局方原案記載条件) Telmisartan tablets (The draft for the Japanese Pharmacopoeia) E130823A Standard solution*(0.08 mg/mL Telmisartan) mAU Telmisartan 200 1 150- 100- 50) System suitabilityrequirement Result Theoretical platenumber(Telmisartan) 23000 5200 Tailing factor(Telmisartan) ≤2.0 1.14 Relative standarddeviation of the peak area(Telmisartan) ≤1.0% 0.06% 0 -50- 0 1 2 3 4 5 6 7 8 9 min Column ： YMC-Triart C18 (5 um， 12nm) 150X4.6mml.D. Eluent ： phosphate buffer (pH 3.0)*2/ methanol (300/700) *Dissolve 2.0 g of (NH4)2HPO4in 1000 mL water， adjust pH 3.0 with H3P04(1→10) Flow rate ： 1.25 mL/min (adjust the flow rate so that the retention time of telmisartan is about 6 min)Temperature ： 40℃ Detection ： UV at 295 nm Injection ： 10 uL (The draft for the Japanese Pharmacopoeia 16th；Assay) *1Standard solution was prepared from Telmisartan supplied as a reagent for laboratory use.