使用QCM-D研究生物材料

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考量生物材料和人体内部环境的生物相容性对于医疗器械来说至关重要。QCM-D是对表面极其敏感的分析仪器,可用来检测表面吸附的物质,包括生物响应以及细胞在表面的吸附。QCM-D分析技术可以解答有多少蛋白质吸附,细胞在不同表面的延展性,细胞响应,表面改性用以提高细胞吸附。而实时的检测办法让其成为一种高效率低样品需要的先进技术。

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APPLICATIONIOVERVIEWBIOMATERIALSasense A CLOSER LOOK AT THESURFACE OF BIOMATERIALS Interactions at the interface between a biomaterial and its physiological environment in the body are critical forthe performance of medical devices. Q-Sense instruments are based on the unique and powerful QCM-D technol-ogy. QCM-D is a surface sensitive technique that enables evaluation of the surface properties of bulk materialsand coatings, including the physiological response of proteins and cells to the surface. A QCM-D analysis can forexample answer questions about how much protein is adsorbed, to what extent cells attach to different materials,the extent of surface induced immune responses and how the surface of a material can be modified to optimizeits function. The real-time analysis that Q-Sense instruments provide is a cost efficient tool in the optimization ofbiomaterial properties, potentially reducing the need for animal studies. QCM-D application examples from literature: 1. Evaluation of material properties of surface coatings ·Build up of polyelectrolyte multilayers ·Swelling of hydrogels ·Viscoelastic properties of polymers, hydrogels and multilayer coatings· Calcification of polyelectrolyte multilayers Polyelectrolyte mulitlayerbuild-up and functionali-sation. 2. Evaluation of interactions between a surface and its physiologicalenvironment Protein-protein interac- ·Hemocompatibility of polymers evaluated by fibrinogen adsorption tions and specificity of binding. · Immune response evaluated by complement factor 3c adsorption ·Cell attachment on functionalized surfaces Measure cell adhesion to different surfaces. ·Protein resistance of contactlenses THE PRODUCT SOLUTION Q-Sense QCM-D instruments are useful tools in biomaterial research ranging from fundamental explorative researchto product development such as orthopedic and dental implants to cardiovascular devices and contact lenses. ·Measure the mass of molecular layers adsorbing ordesorbing from a surface in real-time. ·Structural changes are measured simultaneously toprovide information on the soft-ness and conformational changesof adsorbed layers. · Real time analysis of adsorption, reaction and structural changes ●·Flexible choice of surfacesof molecular layers adsorbingor desorbing from the surface inreal-time. ·Surface modification of the sensors in situ or ex situallows for numerous possibilitiesto functionalize the surface.
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瑞典百欧林科技有限公司为您提供《使用QCM-D研究生物材料》,该方案主要用于其他中--检测,参考标准--,《使用QCM-D研究生物材料》用到的仪器有QSense卓越版四通道石英晶体微天平、QSense Explorer扩展版石英晶体微天平、QSense全自动八通道石英晶体微天平