制药中连续生产检测方案(液体流量计)

T +31(0)573 45 88 00 F +31(0)573 45 88 08 I www.bronkhorst.com E info@bronkhorst.com LIQU-FLOWIM Series L10 / L20 Digital Mass Flow Meters / Controllers for Liquids > Introduction Bronkhorst High-Tech B.V.， the European market leader in thermalMass Flow Meters/Controllers and Electronic Pressure Controllers，has many years experience in designing and manufacturing preciseand reliable measurement and control devices. With a wide rangeof instruments， Bronkhorst offers innovative solutions for manydifferent applications in many different markets. The instruments aremade to customers' specification， in various styles， suitable for usein laboratory， industrial environment， hazardous areas， semiconductorprocessing or analytical equipment. >LIQUI-FLOWTM series L10 / L20 Bronkhorst has been the pioneer in the field of micro to low flowliquid metering instruments based on a thermal measuring principle.The digital LIQUI-FLOWTM Mass Flow Meter was designed to coverthe range between 5 and 1000 g/h (Full Scale) in a compactinstrument with a fast response. The Flow Meter is basically astainless steel tube without any moving parts or built-in obstructions.The heater/sensor assembly is arranged around the tube and， byfollowing the anemometric principle： a constant difference intemperature (AT) is created and the energy required to maintainthe AT is dependent of the mass flow rate. Due to the benefits ofthe unique patented sensor， the fluid will be warmed to a maximumof 5℃， thereby making the L10/L20 series suitable for fluids withlow boiling points. > Liquid flow control Flow control is achieved by integrating a control valve onto thebody of the Liquid Flow Meter， or by mounting it as a separatecomponent [in IP65 configuration). This control valve has a purgeconnection on top of the sleeve that enables easy elimination of airor gas when starting up the system. The electronic control functionforms part of the normal circuitry in the liquid flow meter， so theneed for an external controller is eliminated. > Multi-Bus technology Bronkhorst developed their latest digital instruments according tothe “multi-bus” principle. The basic pc-board on the instrumentcontains all of the general functions needed for measurement and control. It has analog I/O-signals and also an RS23 connection asa standard feature. In addition there is the possibility of integrating aninterface board with DeviceNetTM， PROFIBUS DP， Modbus， EtherCATor FLOW-BUS protocol. > General LIQUI-FLOWTM features ◆fast and accurate measuring signal ●iinsensitive to mounting position ◆ very small internal volume ◆ suitable for liquids with low boiling points ◆ for laboratory and OEM applications ◆also available for industrial applications， with IP65 housing，ATEX Cat.3， Zone 2 > Digital features ◆D[eviceNet M， PROFIBUS DP， Modbus-RTU/ASCII， EtherCATor FLOW-BUS slave ◆ RS232 interface ◆ alarm and counter functions >Fields of application ◆SSemiconductor industry ◆ HPLC applications Chemical industry Food & Pharmaceutical industry ◆ Analytical laboratories > Dimensions and weights Model A B C H K Weight (kg) L13 (1/8”OD) 47 98 47 118 25 0，4 L23 (1/4”OD) 47 102 47 121 25 0，4 Mass Flow Controller IP65 Mass Flow Meter Model A B C H K L Weight (kg) L13I (1/8"OD) 47 98 74 125 25 36 0，9 L23I (1/4”OD) 47 102 74 128 25 36 0，9 Dimensions in mm Model A B C H K L Weight (kg) L13I+C2I (1/8”OD) 127 178 74 125 29 36 1，4 L23I+C2I (1/4”OD) 127 178 74 128 29 36 1，4 > Industrial style LIQUI-FLOWTM series The LIQUI-FLOWTM series L10I/L20I digital Liquid Flow Meters /Controllers for low flow ranges are equipped with a rugged‘industrial style'(IP65) pc-board housing for use in industrialenvironments or even Zone 2 hazardous areas， due to theirATEX category 3 approval. The instruments operate on a thermal，thru-flow measuring principle. The flow meter can be connectedto a control valve to form a closed control loop. The standarddirect acting valve (model C2l) is normally closed， has a pressurecapability of 100 bar (1500 psi) and a purge connection for easyelimination of air or gas. L13I Mass Flow Meter，IP65 configuration IP65 Mass Flow Meter with close-coupled Control Valve > Application examples Verifying pumps LIQUI-FLOWIM flow meters are used in analytical applications incombination with HPLC pumps， verifying the pump performance oreven， as shown in this example， close-coupled with a gear pump.Using the integrated PID controller， the setpoint signal continuouslyadjusts the rotation speed of the pump. GMP validation in food & pharma filling processes In food and pharmaceutical applications critical filling processesmust be very accurately and， above all traceably documented. LIQUI-FLOWIM Series L10/L20 are particularly suitable for this task. Themain features of these digital instruments are： high precision， fastresponse， compact design and a very small internal volume. Bronkhorst High-Tech B.V. Nijverheidsstraat 1a， NL-7261 AK Ruurlo Netherlands Liquid Delivery with Vapour Control The CEM-System (Controlled Evaporation and Mixing) is aninnovative Liquid Delivery System (LDS] that can be applied foratmospheric or vacuum processes. The vapour generation systemconsists of a liquid flow controller，an MFC for carrier gas anda temperature controlled mixing and evaporation device.The system is suitable for mixing liquid flows of 0，25-1200 g/hresulting in saturated vapour flows of 50 ml，/min up to 100 l，/min.This vaporizer system can replace bubblers. New opportunitiescreated with the CEM-system： mixtures can be evaporated andeven solids， dissolved in solvents can be vaporised successfully. Features ◆ Accurately controlled gas/liquid mixture (mass flow) ◆ Fast response ◆ High reproducibility ◆ Handles water， solvents， liquid mixtures ◆ Very stable vapour flow ◆ Flexible selection of gas/liquid ratio ◆ Lower working temperature than conventional system Vapour delivery applications ◆ CCVD (Chemical Vapour Deposition)， e.g. for hardening，thin film coating or planarization processes ◆Testing/calibration of analyzers with reference gasvapor concentrations ◆ T Toxic gas effects on protective clothing ◆ Analyzers with reference H，0 vapour concentrations ◆Humidification of fuels ◆ Anaesthetics 以连续生产取代批量处理是制药行业发展的一大趋势。 与批量处理不同，连续性生产通过不间断地输送原材料和持续地过程处理直到最终产品完成。连续生产制药控制的流量解决方案在连续剂量配料系统中，化学反应物需要以高精准高重复性的方式添加、混合和输送到生产的各个阶段。科里奥利质量流量传感器经常被用于-在液体流量的关键过程控制中实现精准的测量。与泵或比例流量控制阀结合使用，mini CORI-FLOWTM质量流量控制器为制药行业的连续生产提供了一个完美的流量控制解决方案。（超）低流量解决方案集成质量流量计、压力控制器和一台泵，采用数字通信技术形成的一整套连续系统，是制药行业连续生产应用的完美解决方案对比批量控制生产制药，连续生产制药的优势集成过程控制，减少工艺步序• 无需手工操作，安全性高，出错率低• 缩短工艺时间• 提高效率 设施设备占用空间小• 更灵活的操作空间• 减少库存• 降低投资成本，减少半成品消耗• 低碳环保