药物，药品中成分鉴定检测方案(红外光谱仪)

Analytical EquipmentINFRARED FOURIER SPECTROMETERInfraLUM9FT-08EUROPEAN PHARMACOPOEIA 8.0www.lumexinstruments.comi IDENTIFICATION OF DRUGS AND MEDICINES INTRODUCTION Pharmacology， an integral part of medical science， shows rapid development resulting in the discovery of anever-growing number of new drugs and medicines. Unfortunately， the number of counterfeited productsinconsistent with Pharmacopoeia has also increased， underlining the importance of quality control andidentification of drugs. These processes are necessary to prevent the circulation of products that not onlylack the required medicinal properties， but might also be hazardous to human health. The IR spectroscopy techniques provide authentication of substances， identification of active components，and rapid quality control of both source chemicals and ready-made drugs due to the fact that each chemicalsubstance in the composition of a medicine has a unique， identifiable transmission spectrum. MEASURING METHOD Solid drugs and medicines are analyzed in a mixture with KBr as pressed pellets or as an emulsion withsuitable liquid (mull). If the analyzed product is in an emulsified state (ointment)， it is analyzed without anypretreatment. Liquid samples are injected in a cell of suitable path-length with windows made from KBr， CaF2or other materials transparent to infrared radiation in the region of interest. The prepared sample (pellet， emulsion or liquid) is placed into a pellet holder or cell and then the IRspectrum of the Teanalyzed sample is registered. For measurements with the use of a diffuse reflectance accessory， a mixture of the substance with powderedand dried KBr or KCl is used and reflectance spectrum is measured in a sample cup. For measurements with an ATR accessory the substance is placed on a crystal plate (ZnSe， Ge， etc) andpressed so that its ATR spectrum can be registered. EQUIPMENT & REAGENTS The following equipment and reagents are used： InfraLUM FT-08 FTIR spectrometer (with software) . Pellet holder or cells - for transmission or absorption spectra Diffuse reflection accessory - for reflectance spectra ATR accessory (with crystals for ATR and high-pressure clamp) - for ATR spectra Personal computer ADVANTAGES & FEATURES OF InfraLUM。 FT-08 FTIR SPECTROMETERS . Excellent technical specifications Ergonomic design of the spectrometer . Some samples can be analyzed without pretreatment Wide variety of accessories， including a complete line of IR spectroscopy accessories from PIKETechnologies . Automatic validation system of the spectrometer and availability of IQ/OQ/PQ specifications Remote diagnostics of the spectrometer Comprehensible software with integrated calibration module . Additional library search module with a connection to spectra libraries provided by S.T. Japan andthe option for each user to create his/her own libraries. No special training and expertise are neededfor the user to run the software. test09， 0.5AbsS0.4一0.3-0.20.1 Click here to configure displayed label：1097.424072 [1/cm].0.078722 [Abs] Department： PPO-2 Operator： KizhaDA      药理学是医学的一个重要组成部分，在新药的研发数量方法表现了惊人的增长。不幸的是，与药典不符的假冒产品数量也随之增加，更突出了药品质量控制和鉴定的重要性。这些监控对防止那些不仅缺乏基本的药物性能更有可能危害人体健康的药品进入市场是非常必要的。      基于药物成分中的每种化学物质都具有独特的、可识别的透射光谱，因此红外光谱技术可以进行物质的鉴定、活性成分的鉴定以及源化学品和现成药品的快速质量控制。