奥美沙坦酯片中奥美沙坦酯含量检测方案(液相色谱柱)

HHPLCDATASHEET*Standard solution was prepared from Olmesartan medoxomil supplied as a reagent for laboratory use.nt com. cn 才儿头廿儿夕>下卜少三儿锭(日本薬局方記載条件)Olmesartan Medoxomil Tablets (The Japanese Pharmacopoeia)F150113J Standard solution*(0.04 mg/mL Olmesartan medoxomil， 0.01 mg/mL p-Hydroxybenzoic acid isobutyl ester) Column ： Triart C18 ExRS plus (5 pm，8 nm) 150 X4.6mml.D. Eluent ： phosphate buffer (pH 3.4)*/acetonitrile (33/17) Dissolve 2.04 g of KH2PO； in 1000 mL water， adjust pH to 3.4 with a solution of *2 1.73 g of phosphoric acid in 1000 mL water Flow rate ： 1.2 mL/min (adjust the flow rate so that the retention time of olmesartan medoxomil is about 16 min Temperature ：40℃ Detection ： UV at 250 nm Injection ： 10 pL (The Japanese Pharmacopoeia 16th 2nd supplement； Assay) 色谱条件及系统适应性结果见谱图