固定剂量复方药中杂质检测方案(液相色谱仪)

The Agilent 1290 Infinity II High Dynamic Range Diode Array Detection (HDR-DAD) Impurity Analyzer Solution combines the signals from two diode array detectors with different path length Max-Light cartridge cells to increase the linear dynamic UV-range. This solution can be used to detect and quantify main and trace compounds in a single run without exceeding the linear UV-range. Using one DAD with a 10-mm flow cell, typically two injections with different injection volumes are needed to determine low-dose, high-dose, and trace compounds. This Application Note demonstrates that one injection is adequate to reliably quantify low-dose, high-dose, and trace compounds of a fixed-dose combination drug using the Agilent 1290 Infinity II HDR-DAD Impurity Analyzer Solution.