High fidelity legacy-to-modern method transfer on the 6475 triple quadrupole LC/MS platform for large output production labs

The new 6475 triple quadrupole LC/MS system with MassHunter 12 utilizes a unique metadata framework that assists in the direct transfer, import, and resolution of previously created methods. Methods are meant to be directly opened in the acquisition system, such that production labs with a large library of in-use methods require minimum effort for transfer into the new platform.Here we present a demonstration and metadata framework to handle the direct method transfer from a “legacy” triple quadrupole LC/MS instrument to anovel triple quadrupole LC/MS hardware and software platform with minimal adjustments and similar performance for accelerated incorporation into the production environment.