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The degree of substitution for sulfobutyl ether b-cyclodextrin (SBE-b-CD) has historically been characterized by nuclear magnetic resonance spectroscopy, but this approach provides gross values for the degree of substitution. The capillary electrophoresis method described here resolves the mixture of positional and regional isomers based on the degree of sulfo butyl ether substitution. Indirect UV detection has been used, where the detection of cyclodextrin is accomplished by a decrease in background absorbance of the background electrolyte buffer benzoic acid. Ten peaks of SBE-b-CD were well resolved with an optimum pH of 8.0 using an Agilent 50 μm id, 56 cm length bare fused silica capillary. The system suitability requirements were passed as per United States Pharmacopeia (USP), and acceptence criteria for averge degree of substitution 6.2 to 6.9 were met.
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AverageDegreeofSubstitutionofBetadex Sulfobutyl Ether Sodium Usingthe Agilent 7100 CapillaryElectrophoresis System Abstractt The degree of substitution for sulfobutyl ether b-cyclodextrin(SBE-b-CD) hashistorically been characterized by nuclear magnetic resonance spectroscopy， but thisapproach providesgrossvaluesfor the degree of substitution. The capillaryelectrophoresis method described here resolves the mixture of positional and regionalisomers based on the degree of sulfo butyl ether substitution. Indirect UV detectionhas been used， where the detection of cyclodextrin is accomplished by a decrease inbackground absorbance of the background electrolyte buffer benzoic acid. TTen peaksof SBE-b-CD were well resolved with an optimum pH of 8.0 using an Agilent 50 um id，56 cm length bare fused silica capillary. The system suitability requirements werepassed as per United States Pharmacopeia (USP)， and acceptence criteria for avergedegree of substitution 6.2 to 6.9 were met. · Agilent Technologies
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安捷伦科技(中国)有限公司为您提供《精钠盐中磺丁基醚倍他环糊精钠盐的平均取代度检测方案(毛细管电泳仪)》，该方案主要用于其他方便食品中理化分析检测，参考标准--，《精钠盐中磺丁基醚倍他环糊精钠盐的平均取代度检测方案(毛细管电泳仪)》用到的仪器有Agilent 7100 毛细管电泳系统
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