Analysis of Semivolatile Organic Compounds with US EPA 8270E Using the Agilent 7000E Triple Quadrupole GC/M

Abstract This application note illustrates a sensitive method used to analyze semivolatile organic compounds (SVOCs) on an Agilent 7000E triple quadrupole GC/MS system (GC/TQ). The use of GC/TQ instrumentation for analysis of SVOCs offers significant advantages. High selectivity afforded by multiple reaction monitoring (MRM) mode results in faster batch review and increased confidence due to the elimination of matrix interferences. These interferences are often present when using selective ion monitoring (SIM) or scan acquisition modes. Increased sensitivity can facilitate smaller extraction volumes that improve sustainability, reduce waste, and decrease costs associated with sample preparation, solvent usage, and waste disposal. A primary objective of this work was to demonstrate the ability of a GC/TQ to detect SVOCs at low levels to meet these laboratory needs while maintaining an excellent dynamic range.