奥美沙坦酯中含量测定检测方案(液相色谱柱)

HHPLC DATASHEET*Standard solution was prepared from Olmesartan medoxomil supplied as a reagent for laboratory use.nt com cn 才儿头廿儿夕沙下丰少三儿(日本薬局方記載条件)Olmesartan Medoxomil (The Japanese Pharmacopoeia)F150113K Standard solution*(0.05 mg/mL Olmesartan medoxomil， 0.025 mg/mL p-Hydroxybenzoic acid isobutyl ester) Column ： Triart C18 ExRS plus (5 pm，8 nm) 150 X4.6 mml.D. Eluent ： phosphate buffer (pH 3.4)*/acetonitrile (33/17) Dissolve 2.04 g ofKH2PO；in 1000 mL water， adjust pH to 3.4 with a solution of *2 1.73 g of phosphoric acid in 1000 mL water Flow rate ： 1.2 mL/min (adjust the flow rate so that the retention time of olmesartan medoxomil is about 16 min Temperature ： 40℃ Detection ： UV at 250 nm Injection ：10pL (The Japanese Pharmacopoeia 16th 2nd supplement； Assay) 色谱条件及系统适用性结果见谱图。