富马酸喹硫平片中溶出度检测方案(液相色谱柱)

HPLC DATA 'SHEET 夕工于了匕少7又儿酸墟锭Quetiapine fumarate fine tablets P130808D Dissolution： Standard solution*'(0.016 mg/mL Quetiapine fumarate) Column ：YMCbasic (5 um， 20 nm) 75X4.6mml.D. Eluent ：methanol/acetonitrile/(NH4)2HPO4aq *2 (54/7/39) *Dissolve 3.3 g of (NH4)2HPO4 in 1250 mL of waterFlow rate ： 1.0 mL/min (adjust the flow rate so that the retention time of quetiapine is about 4 min)Temperature ：25℃Detection ： UV at 230 nm Injection ： 50 uL (Modified condition of The Japanese Pharmacopoeia 16th Supplement I； Dissolution) * Standard solution was prepared from Quetiapine fumarate supplied as a reagent for laboratory use. 色谱条件见谱图