别称
AOA, AOA1, aprataxin, APTX, AXA1, EAOH, EOAHA, FHA HIT
宿主
Rabbit
适应种属
Human
亚型
IgG
验证应用
ELISA, WB, IHC
产品信息
产品名称
anti- APTX antibody
货号
QSab10359
规格
100μg
状态
liquid
纯化方法
Immunogen affinity purified
纯度
≥95% as determined by SDS-PAGE
宿主
Rabbit
克隆性
polyclonal
亚型
IgG
存储
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
背景介绍
APTX, also named as Aprataxin, is a nuclear protein, present in both the nucleoplasm and the nucleolus, which is a member of the histidine triad (HIT) superfamily. APTX is involved in DNA single-strand break repair, mediating protein-protein interactions with molecules responding to DNA damage. APTX contains three conserved domains: an N-terminal forkhead-associated (FHA) domain which mediates protein-protein interactions, a HIT domain that is similar to Hint, and a C-terminal zinc finger domain. Loss of function mutations in APTX, the gene encoding for Aprataxin, destabilize the Aprataxin protein and result in a rare neurological disorder known as ataxia-oculomotor apraxia, characterized by abnormal movements of the head and eyes.
免疫原信息
免疫原
aprataxin
别称
AOA, AOA1, aprataxin, APTX, AXA1, EAOH, EOAHA, FHA HIT
分子量
40 kDa
应用
验证应用
ELISA, WB, IHC
建议稀释比例
WB: 1:500 - 1:2000; IHC: 1:20 - 1:200