anti- APOBEC3C antibody

 别称

APOBEC1L, PBI

 宿主

Rabbit

 适应种属

Human

 亚型

IgG

 验证应用

ELISA, IHC, WB

产品信息

产品名称

anti- APOBEC3C antibody

货号

QSab00494

规格

100μg

状态

liquid

纯化方法

Immunogen affinity purified

纯度

≥95% as determined by SDS-PAGE

宿主

Rabbit

克隆性

polyclonal

亚型

IgG

存储

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

背景介绍

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and-independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV) , hepatitis B virus (HBV) , herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

免疫原信息

免疫原

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C

别称

APOBEC1L, PBI

分子量

23 kDa

应用

验证应用

ELISA, IHC, WB

建议稀释比例

WB: 1:500-1:2000; IHC: 1:20-1:200