别称
HME, Macrophage elastase, Macrophage metalloelastase, Matrix metalloproteinase 12, ME, MME, MMP 12, MMP12
宿主
Rabbit
适应种属
Human, Mouse
亚型
IgG
验证应用
ELISA, WB, IHC, IF
产品信息
产品名称
anti- MMP12 antibody
货号
QSab05234
规格
100μg
状态
liquid
纯化方法
Immunogen affinity purified
纯度
≥95% as determined by SDS-PAGE
宿主
Rabbit
克隆性
polyclonal
亚型
IgG
存储
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
背景介绍
MMP12 (Matrix metalloproteinase-12) is a 54 kDa proenzyme that is processed into a 45 kDa and then a 22 kDa active form (15723202) . MMP9 and MMP12 promote intimal thickening by independent cleavage of N-cadherin, which elevates vascular smooth muscle cell proliferation via beta-catenin signalling. Its overexpression in myeloid lineage cells plays a key role in modulating myelopoiesis, immune suppression, and lung tumorigenesis (PMID: 21378275) .
免疫原信息
免疫原
matrix metallopeptidase 12 (macrophage elastase)
别称
HME, Macrophage elastase, Macrophage metalloelastase, Matrix metalloproteinase 12, ME, MME, MMP 12, MMP12
分子量
54 kDa, 45 kDa
应用
验证应用
ELISA, WB, IHC, IF
建议稀释比例
WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100