别称
CARD adapter inducing interferon beta, Interferon beta promoter stimulator protein 1, Cardif, Putative NF-kappa-B-activating protein 031N, Virus-induced-signaling adapter
宿主
Rabbit
适应种属
Human, Mouse
亚型
IgG
验证应用
ELISA, WB, IF, IP, IHC
产品信息
产品名称
anti- MAVS; VISA antibody
货号
QSab05032
规格
100μg
状态
liquid
纯化方法
Immunogen affinity purified
纯度
≥95% as determined by SDS-PAGE
宿主
Rabbit
克隆性
polyclonal
亚型
IgG
存储
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
背景介绍
Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5) . Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.It can undergoe phosphorylation on multiple sites and ubiquitination, which may together cause the molecular weight migrate to about 70 kDa despite the predicated 57 kDa.
免疫原信息
免疫原
mitochondrial antiviral signaling protein
别称
CARD adapter inducing interferon beta, Interferon beta promoter stimulator protein 1, Cardif, Putative NF-kappa-B-activating protein 031N, Virus-induced-signaling adapter
分子量
70 kDa
应用
验证应用
ELISA, WB, IF, IP, IHC
建议稀释比例
WB: 1:1000-1:4000; IP: 1:500-1:2000; IHC: 1:100-1:500; IF: 1:10-1:100
更多
企业名称
上海钦胜生物科技有限公司
企业信息已认证
企业类型
信用代码
27000000202008180010
成立日期
2020-08-18
注册资本
100
经营范围
从事生物科技、医疗科技领域内的技术开发、技术咨询、技术转让;仪器仪表、机电设备、机械设备、玻璃制品、电子产品、医疗器械、化工产品及原料(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品)的销售。 【依法须经批准的项目,经相关部门批准后方可开展经营活动】
上海钦胜生物科技有限公司
公司地址
上海市松江区余山镇陶干路701号5幢
客服电话