别称
A4, ABPP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, Beta-amyloid precursor protein, CVAP, PreA4
宿主
Mouse
适应种属
Human, Pig
亚型
IgG2a
验证应用
ELISA, WB, IHC
产品信息
产品名称
anti- APP antibody
货号
QSab00513
规格
100μg
状态
liquid
纯化方法
Protein A+G purification
纯度
≥95% as determined by SDS-PAGE
宿主
Mouse
克隆性
monoclonal
亚型
IgG2a
存储
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
背景介绍
Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu (2+) and Fe (3+) to Cu (+) and Fe (2+) , respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts. The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
免疫原信息
免疫原
amyloid beta A4 precursor protein
别称
A4, ABPP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, Beta-amyloid precursor protein,
CVAP, PreA4
分子量
100 kDa
应用
验证应用
ELISA, WB, IHC
建议稀释比例
WB: 1:500-1:2000; IHC: 1:50-1:500