别称
ABH7, ALKBH7, SPATA11, UNQ6002
宿主
Rabbit
适应种属
Human, Mouse, Rat
亚型
IgG
验证应用
ELISA, WB, IHC
产品信息
产品名称
anti- ALKBH7 antibody
货号
QSab00315
规格
100μg
状态
liquid
纯化方法
Immunogen affinity purified
纯度
≥95% as determined by SDS-PAGE
宿主
Rabbit
克隆性
polyclonal
亚型
IgG
存储
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
背景介绍
May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro) , but this activity may be due to the absence of the true substrate (PubMed:25122757) . Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923) . ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923) . Does not display DNA demethylase activity (PubMed:23666923) . Involved in fatty acid metabolism (By similarity) .
免疫原信息
免疫原
alkB, alkylation repair homolog 7 (E. coli)
别称
ABH7, ALKBH7, SPATA11, UNQ6002
分子量
25 kDa
应用
验证应用
ELISA, WB, IHC
建议稀释比例
WB :1:200-1:2000; IHC: 1:20-1:200