别称
ALK, ALK tyrosine kinase receptor, ALK, CD246, Anaplastic lymphoma kinase, CD246, TFG/ALK
宿主
Mouse
适应种属
Human
亚型
IgG2a
验证应用
ELISA, IHC, WB
产品信息
产品名称
anti- ALK,CD246 antibody
货号
QSab00310
规格
100μg
状态
liquid
纯化方法
Protein A+G purification
纯度
≥95% as determined by SDS-PAGE
宿主
Mouse
克隆性
monoclonal
亚型
IgG2a
存储
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
背景介绍
ALK, also named as CD246, is a receptor tyrosine kinase (RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM (Nucleophosmin) -ALK oncogenic fusion protein, resulting from the (2;5) (p23;q35) translocation that is frequently associated with anaplastic large-cell lymphoma (ALCL) . The EML4 (echinoderm microtubule-associated protein-like 4) -ALK fusion protein have been described in non-small-cell lung cancer (NSCLC) , this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC (PMID: 17625570) .
免疫原信息
免疫原
anaplastic lymphoma receptor tyrosine kinase
别称
ALK, ALK tyrosine kinase receptor, ALK, CD246, Anaplastic lymphoma kinase, CD246, TFG/ALK
分子量
176 kDa
应用
验证应用
ELISA, IHC, WB
建议稀释比例
WB :1:500-1:5000; IHC: 1:20-1:200