anti- ALDH2 antibody

别称

ALDH class 2, ALDH E2, ALDH2, ALDHI, ALDM

 宿主

Rabbit

 适应种属

Human, Mouse, Rat

 亚型

IgG

 验证应用

ELISA, WB, IHC, IF

产品信息

产品名称

anti- ALDH2 antibody

货号

QSab00291

规格

100μg

状态

liquid

纯化方法

Immunogen affinity purified

纯度

≥95% as determined by SDS-PAGE

宿主

Rabbit

克隆性

polyclonal

亚型

IgG

存储

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

背景介绍

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

免疫原信息

免疫原

aldehyde dehydrogenase 2 family (mitochondrial)

别称

ALDH class 2, ALDH E2, ALDH2, ALDHI, ALDM

分子量

53 kDa

应用

验证应用

ELISA, WB, IHC, IF

建议稀释比例

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200