别称
ALCAM, CD166, CD166 antigen, FLJ38514, MEMD
宿主
Rabbit
适应种属
Human
亚型
IgG
验证应用
ELISA, IHC, WB
产品信息
产品名称
anti- ALCAM antibody
货号
QSab00280
规格
100μg
状态
liquid
纯化方法
Immunogen affinity purified
纯度
≥95% as determined by SDS-PAGE
宿主
Rabbit
克隆性
polyclonal
亚型
IgG
存储
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
背景介绍
Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728) . Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728) . Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806) . Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806) . Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813) . Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771) . Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771) . Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity) . Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity) . Isoform 3: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation.
免疫原信息
免疫原
activated leukocyte cell adhesion molecule
别称
ALCAM, CD166, CD166 antigen, FLJ38514, MEMD
分子量
110 kDa
应用
验证应用
ELISA, IHC, WB
建议稀释比例
WB :1:200-1:2000; IHC: 1:20-1:200