别称
A kinase anchor protein 8 like, AKAP8 like protein, AKAP8L, DKFZp434L0650, HA95, HAP95, Helicase A binding protein 95, Homologous to AKAP95 protein, NAKAP, NAKAP95, Neighbor of AKAP95
宿主
Rabbit
适应种属
Human
亚型
IgG
验证应用
ELISA, WB, IF
产品信息
产品名称
anti- AKAP8L antibody
货号
QSab00258
规格
100μg
状态
liquid
纯化方法
Immunogen affinity purified
纯度
≥95% as determined by SDS-PAGE
宿主
Rabbit
克隆性
polyclonal
亚型
IgG
存储
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
背景介绍
Could play a role in constitutive transport element (CTE) -mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034) . Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601) . May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899) . May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639) . Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585) . May be involved in regulation of pre-mRNA splicing (PubMed:17594903) . (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters (PubMed:11884601) . Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses (PubMed:11402034) . In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA (Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity (PubMed:25034436) .
免疫原信息
免疫原
A kinase (PRKA) anchor protein 8-like
别称
A kinase anchor protein 8 like, AKAP8 like protein, AKAP8L, DKFZp434L0650, HA95, HAP95, Helicase A binding protein 95, Homologous to AKAP95 protein, NAKAP, NAKAP95, Neighbor of AKAP95
分子量
72 kDa
应用
验证应用
ELISA, WB, IF
建议稀释比例
WB :1:200-1:2000; IF: 1:20-200
UNIPROT 信息
更多
企业名称
上海钦胜生物科技有限公司
企业信息已认证
企业类型
信用代码
27000000202008180010
成立日期
2020-08-18
注册资本
100
经营范围
从事生物科技、医疗科技领域内的技术开发、技术咨询、技术转让;仪器仪表、机电设备、机械设备、玻璃制品、电子产品、医疗器械、化工产品及原料(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品)的销售。 【依法须经批准的项目,经相关部门批准后方可开展经营活动】
上海钦胜生物科技有限公司
公司地址
上海市松江区余山镇陶干路701号5幢
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