别称
AGAP 2, AGAP2, Centaurin gamma 1, CENTG1, Cnt g1, FLJ16430, GGAP2, KIAA0167, PIKE
宿主
Rabbit
适应种属
Human, Mouse, Rat
亚型
IgG
验证应用
ELISA, WB, IHC, IF
产品信息
产品名称
anti- AGAP2 antibody
货号
QSab00205
规格
100μg
状态
liquid
纯化方法
Immunogen affinity purified
纯度
≥95% as determined by SDS-PAGE
宿主
Rabbit
克隆性
polyclonal
亚型
IgG
存储
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
背景介绍
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1) -dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
免疫原信息
免疫原
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
别称
AGAP 2, AGAP2, Centaurin gamma 1, CENTG1, Cnt g1, FLJ16430, GGAP2, KIAA0167, PIKE
分子量
125 kDa
应用
验证应用
ELISA, WB, IHC, IF
建议稀释比例
WB :1:500-1:5000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
更多
企业名称
上海钦胜生物科技有限公司
企业信息已认证
企业类型
信用代码
27000000202008180010
成立日期
2020-08-18
注册资本
100
经营范围
从事生物科技、医疗科技领域内的技术开发、技术咨询、技术转让;仪器仪表、机电设备、机械设备、玻璃制品、电子产品、医疗器械、化工产品及原料(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品)的销售。 【依法须经批准的项目,经相关部门批准后方可开展经营活动】
上海钦胜生物科技有限公司
公司地址
上海市松江区余山镇陶干路701号5幢
客服电话