别称
AATF, CHE 1, CHE1, DED, Protein AATF, Rb binding protein Che 1, Traube
宿主
Rabbit
适应种属
Human, Mouse, Rat
亚型
IgG
验证应用
ELISA, WB, IF
产品信息
产品名称
anti- AATF antibody
货号
QSab00025
规格
100μg
状态
liquid
纯化方法
Immunogen affinity purified
纯度
≥95% as determined by SDS-PAGE
宿主
Rabbit
克隆性
polyclonal
亚型
IgG
存储
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
背景介绍
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia) , although the molecular basis for this phenomenon has not been described to date.
免疫原信息
免疫原
apoptosis antagonizing transcription factor
别称
AATF, CHE 1, CHE1, DED, Protein AATF, Rb binding protein Che 1, Traube
分子量
63 kDa
应用
验证应用
ELISA, WB, IF
建议稀释比例
WB: 1:200-1:2000; IF: 1:10-1:100
更多
企业名称
上海钦胜生物科技有限公司
企业信息已认证
企业类型
信用代码
27000000202008180010
成立日期
2020-08-18
注册资本
100
经营范围
从事生物科技、医疗科技领域内的技术开发、技术咨询、技术转让;仪器仪表、机电设备、机械设备、玻璃制品、电子产品、医疗器械、化工产品及原料(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品)的销售。 【依法须经批准的项目,经相关部门批准后方可开展经营活动】
上海钦胜生物科技有限公司
公司地址
上海市松江区余山镇陶干路701号5幢
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