BCEIA 2023生命科学中的分析技术分会预告：关注生命、聚焦方法

第二十届北京分析测试学术报告会暨展览会（BCEIA 2023）将于2023年9月6—8日在北京· 中国国际展览中心(顺义馆)召开。作为中国分析与生化技术交流与展示的“峰会”，BCEIA 2023将营造浓郁的学术会展氛围，同期举办大会报告、分会报告、高峰论坛、同期会议、墙报展等精彩学术活动，面向世界科技最前沿，邀请国内外顶尖学者分享最具前瞻性的研究进展。

2023年9月7-8日，BCEIA 2023学术报告会——生命科学中的分析技术分会将在南登录大厅学术会议区 E-201会议室举行，聚焦“关注生命、聚焦方法”主题，围绕精准医学诊断、组学分析、生物医药分析、健康与安全相关新技术新方法等几个专题方向，邀请到19位国内检验医学领域资深科学家及青年才俊带来精彩报告。

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报告摘要

Rapid detection of infectious pathogens is vital for preventing costless outbreaks and improving human health. Current detection methods oftentimes lack the means to detect infectious pathogens in a simple, rapid, and reliable manner at the time and point of need. Functional nucleic acids (FNAs) – specifically DNA aptamers and DNAzymes – have the potential to overcome these limitations by acting as key components for point-of-care (POC) biosensors due to their distinctive advantages that include high binding affinities and specificities, excellent chemical stability, ease of synthesis and modification, and compatibility with a variety of signal-amplification and signal-transduction mechanisms. In this presentation, I will discuss the work completed or on-going in my laboratory, in collaboration with several other groups at McMaster University, towards developing simple-to-use analytical devices with integrated FNAs to detect bacterial and viral pathogens, such as E. coli, Salmonella, SARS-CoV-2, porcine epidemic diarrhea virus (PEDV), directly in water, food or clinical samples.

专家简介

Yingfu Li is a Professor in the Department of Biochemistry and Biomedical Sciences at McMaster University. He was born and raised in Anhui, China, received his BSc in chemistry at Anhui University in 1983, and his MSc in applied chemistry at China Agriculture University in 1989. He moved to Canada in 1992 and earned a PhD in Biochemistry from Simon Fraser University in 1997. His PhD work won him Governor General of Canada Academic Gold Medal and Natural Sciences and Engineering Research Council of Canada Doctoral Prize. He carried out his postdoctoral research at Yale University between 1997-1999 with a fellowship from Medical Research Council of Canada. In November 1999, he joined McMaster University as an Assistant Professor in the Department of Biochemistry and Biomedical Sciences, was promoted to a Full Professor by 2010. He has published extensively on functional nucleic acids, including ~300 research papers, review articles, and book chapters. He has also served as an Associate Editor of Journal of Molecular Evolution and Co-Editor-in-Chief of Advanced Agrochem. He has received many recognitions, including Canada Research Chair, New Investigator Award from the Canadian Institute of Health Research, Premier Research Excellent Award from Ontario Government, and McBryde Medal from Canadian Society of Chemistry.

报告摘要

Nucleic acid-binding proteins assume crucial roles in all aspects of nucleic acid metabolism, including DNA replication, transcription and repair.  In this presentation, I will discuss our studies in using mass spectrometry-based quantitative proteomic approaches for uncovering novel cellular proteins that can recognize guanine quadruplex DNA and modified nucleosides in RNA.  The functional characterizations of selected new nucleic acid-recognition proteins, including their roles in long-range DNA looping and nucleotide repeat expansion diseases, will also be presented. Through this presentation, I hope to illustrate that bioanalytical chemistry constitutes a powerful approach for revealing novel functions of nucleic acid-binding proteins.

专家简介

Yinsheng Wang received his Ph. D. degree from Washington University in St. Louis after obtaining his BS and MS degrees from Shandong University and Dalian Institute of Chemical Physics, Chinese Academy of Sciences, respectively.  He joined the faculty of the University of California Riverside in 2001, where he is now a Distinguished Professor and Donald T. Sawyer Endowed Founder's Chair in Chemistry. His current research involves the use of mass spectrometry, synthetic organic chemistry, molecular biology, genetic and genomic tools for assessing the occurrence, repair and biological consequences of DNA damage. His ongoing research also includes functional characterizations of modified nucleosides in RNA and their implications in human diseases.  Yinsheng has trained or in the process of training of over 90 Ph. D. students and post-doctoral fellows, and he has co-authored over 350 research articles. He has served as an Associate Editor for Chemical Research in Toxicology since 2018.  He was the recipient for the American Society for Mass Spectrometry (ASMS) Research Award in 2005, Chemical Research in Toxicology Young Investigator Award in 2012, the ASMS Biemann Medal in 2013, and the Founders Award from the Division of Chemical Toxicology of the ACS in 2023. He was elected as a Fellow for the American Association for the Advancement of Sciences in 2012.

报告摘要

Many of the classic aptamers bind purine derivatives such as adenosine, ATP, and theophylline, but most of the previous selections were carried out using the target immobilization method. Our lab has revisited some of the same target molecules including theophylline, adenosine and also some new targets such as caffeine and uric acid using the library immobilization method. Interesting new aptamers were obtained showing dissociation constants in the nanomolar to low micromolar range as characterized using isothermal titration calorimetry. Cross-binding of different purines by aptamers was also studied. Given the biological importance of purine derivatives, biosensors were also designed for their detection.

专家简介

Juewen Liu received his Bachelor’s degree from the University of Science & Technology of China in 2000 and Ph.D. from the University of Illinois at Urbana-Champaign in 2005. He joined the University of Waterloo in 2009 and is currently a professor of chemistry. He is interested in aptamers and biosensors. He received a Fred Beamish Award (2014) and a McBryde Medal (2018) from the Canadian Society for Chemistry for his contribution in bioanalytical chemistry. He is a College member of the Royal Society of Canada. He serves as a Section Editor for Biosensors & Bioelectronics, and a Contributing Editor for TrAC Trends in Analytical Chemistry. He has published over 400 papers, receiving over 38,000 citations with an H-index of 94, and is a Clarivate Highly Cited Researcher in 2022.

报告摘要

Along with infectious diseases, cancer is another leading cause of death worldwide. Although different types of biomolecular quantitation methods such as ELISA have been widely used for cancer biomarker detection, they have limited applications in low-resource settings due to their dependence on expensive and bulky analytical instruments such as microplate readers and fluorescence microscopes. There is an urgent demand to develop simple and low-cost biosensing methods to address those challenges. Hence, we developed various nanomaterial-mediated biosensing techniques for early detection of cancer biomarkers at the point of care. For instance, we, for the first time, developed an innovative photothermal immunoassay for cancer biomarker detection using a common thermometer. In addition, we discovered the photothermal effect of TMB and applied it for quantitative cancer biomarker detection using a thermometer for low-resource settings. Although we did not use expensive instruments, the sensitivity is comparable to UV-Vis methods using a spectrometer.

专家简介

XiuJun (James) Li, Ph.D., is a Full Professor with early tenure in the Department of Chemistry and Biochemistry at the University of Texas at El Paso (UTEP), USA. He is also the Director of Forensic Science Program at UTEP. After he obtained his Ph.D. degree from Simon Fraser University (SFU) in Canada in 2008, he pursued his postdoctoral research with Prof. Richard Mathies at University of California Berkeley and Prof. George Whitesides at Harvard University, while holding a Postdoctoral Fellowship from Natural Sciences and Engineering Research Council (NSERC) of Canada. Dr. Li’s current research interest is centered on the development of innovative microfluidic lab-on-a-chip and nanotechnology for bioanalysis, biomaterial, biomedical engineering, and environmental applications, including but not limited to low-cost diagnosis, pathogen detection, nano-biosensing, genetic analysis, 3D cell culture, tissue engineering, and single-cell analysis. His lab has extensive experience in point-of-care detection. He pioneered the novel concept of paper/polymer hybrid microfluidic devices; he, for the first time, developed photothermal biosensors for low-cost quantitative analysis using a common thermometer.

Dr. Li has coauthored more than 117 journal publications and 23 patents, including three books from Elsevier on microfluidic devices for biomedical applications. He is an Editorial Board member of multiple journals including Microsystems & Nanoengineering and Scientific Reports from the Nature Publishing Group, Micromachines, Future Science OA, Journal of Analysis and Testing, etc, and an Advisory Board member of Lab on a Chip and Analyst. He is the recipient of the “Bioanalysis New Investigator Award” in 2014, UT STARS Award in 2012, NSERC Postdoctoral Fellow Award in 2009, Chinese Government Award for Outstanding Self-financed Graduate Student Abroad (2004), Outstanding Faculty Dissertation Research Mentoring Award (2016 & 2018, twice), NIH BUILDING Scholar Mentoring Award for Excellence in Student Research Mentoring in 2017, and so on.

专家简介

Dr. Xiaomei Yan is a distinguished professor of Xiamen University, China. She is the winner of the National Science Fund for Distinguished Young Scholars of China in 2012 and was enrolled in the National Ten Thousand Talent Program in 2016. She is interested in the development of advanced instrumentation and methodologies for biochemical and biomedical analysis. In particular, she has developed world-leading nano-flow cytometry (nFCM) by capitalizing on light-scattering and fluorescence from individual biological nanoparticles. nFCM enables multiparameter quantification of particle size and size distribution, particle concentration, and biochemical properties of individual extracellular vesicles, viruses, and nanomedicines at a throughput up to 10,000 particles/min. The sizing resolution is comparable to transmission electron microscopy (TEM). nFCM has now been commercialized and become a popular tool for many internationally renowned institutions and universities, such as Mayo Clinic, National Cancer Institute of National Institutes of Health, MD Anderson Cancer Center, and Oxford University. The application areas of customers include extracellular vesicle diagnosis and treatment, mRNA vaccine, cell and gene therapy vector, and novel nanomedicine delivery vectors.

报告摘要

Next-generation risk assessment for environmental chemicals involves a weight of evidence framework integrating a suite of new approach methodologies based on points of departure obtained from in vitro assays. Among existing new approach methodologies, the omic-based technologies are of particular importance based on the premise that any apical endpoint change indicative of impaired health must be underpinned by some alterations at the omics levels, including such as the transcriptome, proteome, metabolome, proteome, epigenome and genome. Transcriptomics assays especially plays a leading role by in providing relatively conservative points of departure in comparison with apical endpoints. However, it is unclear whether and how parameters measured using other omics techniques predict the cellular response to chemical perturbations, especially at exposure levels below the transcriptomically defined points of departure. Multi-omics coverage may provide additional sensitive or confirmative biomarkers to complement and reduce the uncertainty in safety decisions made using targeted and transcriptomics assays. In the present study, we conducted multi-omics studies of compared changes in transcriptomics, proteomics and phosphoproteomics with varied types of compounds with multiple chemical concentrations and time points, to understand the sensitivity of the three omics techniques in response to chemically-induced changes in HepG2. We demonstrated that phosphoproteomics alterations occur not only earlier in time, but also at much more sensitive to lower concentrations than proteomics and transcriptomics, and hence are proximal to the very early effects induced by chemical exposure. The phosphoproteomics changes appear to maximum when the transcriptomics alterations begin to be initiated.

专家简介

Ping Xu, Ph.D, Principal Investigator of the Protein Posttranslational Modification of National Center for Protein Sciences Beijing. He is also the Vice President of Asia Oceania Human Proteome Organization (AOHUPO) and the President of Chinese Human Proteome Organization (CNHUPO).

His major interests focus on the biological function of protein post-translational modification, especially protein ubiquitination and regulation of protein ubiquitination in the occurrence and development of tuberculosis and liver disease by proteomics approaches. His research involves state-of-art technologies for profiling thousands of proteins and posttranslational modifications by quantitative mass spectrometry and large scale data processing. He co-chaired the Chromosome-Centric Human Proteome Project in China. He has also published over 120 peer-reviewed papers on series top journals, including Cell, Mol Cell, Gastroenterology、Nat Commun、J Hepatol、MCP. He was awarded multiple academic awards at home and abroad.

报告摘要

Polysorbate 80 (PS80) is widely used as an excipient in vaccines and biopharmaceuticals. The oxidized species of PS80 have raised concern because of their potential to compromise product stability and pose a clinical risk. Analytical methods to profile and identify the oxidized species are hard to develop owing to their complexity and low abundance. Herein, a novel strategy was demonstrated to comprehensively profile and identify the oxidized species of PS80 using ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. A total of 348 (32 types) oxidized species were profiled and identified in the oxidized PS80 samples, including 119 (10 types) species found for the first time to our knowledge. Mathematical models were established and validated based on the good logarithmic relation between the POE degree of polymerization and the relative retention time and used to rapidly discover and identify the oxidized species. A novel strategy was established to profile and identify the PS80 oxidized species based on their retention time, HRMS, and HRMS2 data of the detected peaks using an in-house dataset. Using this strategy, 104 (14 types) and 97 (13 types) oxidized species were identified for the first time in PS80 and its preparations, respectively.

专家简介

Dr. Zhang is appointed as professor of Institute of Materia Medica, Chinese Academy of Medical Sciences (CAMS). She received her B.S. degree in Pharmacy, from College of Pharmacy, Beijing University, and his Ph.D. degree in pharmaceutical analysis from Peking Union Medical College. Her current research interest mainly focuses on metabolism of new drugs and nature products by hybrid tandem mass spectrometry techniques, development of new analytical method for metabolomics and biomarkers related to disease, quality control and ADME study of new drug. Dr. Zhang has published about 70 peer-reviewed SCI papers.

报告摘要

Aptamer selection using diseased cells as targets (Cell-SELEX) usually obtains a group of aptamers against different molecular targets present on cell surface in their active and native states. The obtained aptamer can serve as molecular ligands for isolation/detection of specific cells, exosomes and biomarkers, as well as for diagnosis and therapy. Given the complexity and diversity of disease cells, cell-SELEX provides the chances to obtain aptamers that specifically bind previously unknown molecular signatures, leading to the discovery of potential biomarkers or even unexpected molecular events on cells. However, there are many challenges in the applications of these aptamers, especially in the applications of diagnosis and therapy. Here we will discuss these challenges while introducing our recent work progress in Cell-SELEX.

专家简介

Dihua Shangguan, Professor, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing. He received his B.S. from Chinese Pharmaceutical University in 1992; and M.S. from Institute of Medicinal Biotechnology, Peking Union Medical College, Chinese Academy of Medical Sciences in 1998. He earned his Ph.D. from ICCAS in 2001, and obtained postdoctoral training in University of Florida (USA) from 2003-2006. His principal research fields are bioanalysis and molecular recognition, including aptamer selection and applications, cell imaging, biomarker discovery and molecular diagnosis.

专家简介

Bi-Feng Yuan studied biochemistry and biophysics at Wuhan University in China, where he received his BSc and Ph.D. degrees in 2001 and 2006, respectively. From 2006-2007 and 2007-2010, he worked as a postdoctoral researcher in the Department of Biological Sciences at National University of Singapore and in the Department of Chemistry at University of California Riverside, respectively. He joined the Department of Chemistry of Wuhan University in 2011. Now he is a professor in School of Public Health of Wuhan University. His research focuses on the development and application of new analytical techniques in the investigation of the occurrence, location, and biological functions of nucleic acid modifications. His research has resulted in more than 100 peer-reviewed journal papers, more than 90 refereed conference papers and presentations.

专家简介

Tiannan Guo received training of clinical medicine (1999-2006) in Tongji Medical College, Huazhong University of Science and Technology, and learned biology (2001-2005) in Wuhan University, before he moved to Singapore for PhD training in cancer proteomics (2008-2012) in the laboratories of Dr. Newman Sze in Nanyang Technological University and Dr. Oi Lian Kon in National Cancer Centre Singapore. In 2012, Tiannan started his postdoctoral training in the laboratory of Dr. Ruedi Aebersold in ETH Zurich. Tiannan moved to Sydney as the Scientific Director of ProCan, group leader of Cancer Proteome, Children’s Medical Research Institute, and the conjoint senior lecturer in The University of Sydney Medical School, in March 2017.

Tiannan joined the Westlake Institute for Advanced Studies, Westlake University in August 2017 as a Tenure Track Assistant Professor and has been promoted to be a Tenure Track Associate Professor since February 2023. He is the director of iMarker lab at Westlake Laboratory since 2020, and an associate faculty member of Research Center for Industries of the Future at Westlake University. He also serves as a council member of Human Proteome Organization (HUPO), chair of Education and Training Committee, co-chair of HUPO B/D HPP Human Cancer Proteome Project, a member of the HUPO Marketing and Outreach Committee, the secretary general of Chinese Proteome Organization (CN-HUPO), and member of the China Physical Society Mass Spectrometry Branch. He also serves in multiple journals including Molecular & Cellular Proteomics, Clinical Proteomics, Scientific Data, Cell Reports Medicine, Proteomics, Proteomics Clinical Applications, Urine, and Genomics Proteomics Bioinformatics.

His research focuses on proteomic technological development and applications in precision medicine. He and colleagues developed pressure-cycling technology coupled with SWATH mass spectrometry to enable an effective proteomic analysis of biopsy tissues (Nature Medicine, 2015; Nature Protocols, 2022). His team reported the first proteomic and metabolic profiles of COVID-19 sera (Cell, 2020), and the first proteomic landscape for COVID-19 autopsies (Cell, 2021a), offering novel approaches and insights into the diagnosis and treatment of COVID-19. With a focus on clinical proteomics technologies (Cell, 2021b), his team is exploring AI-empowered proteomic big data for precision medicine with a focus on thyroid nodule diagnosis (Cell Discovery, 2022).

报告摘要

The immunoassay based on antigen-antibody recognition is the mainstream technology for small molecular compounds detection in animal-derived foods, such as veterinary drugs, illegal additives and mycotoxins. High-performance antibodies are the core element for the establishment of immunoassays for detecting small molecules, determining the sensitivity, specificity and stability of the immunoassays. The traditional antibody preparation technologies of small molecular compounds are limited by the low effective fusion efficiency of mouse hybridoma cells, the lack of preparation technology of rabbit monoclonal antibodies, the low success rate of preparation and the poor affinity of camel nanobodies, which can hardly meet the development needs of immunoassay. In addition, the non-physiological environment such as organic solvent and high salt introduced by the pretreatment of food samples can easily lead to antibody denaturation, which results in that the detection performance and detection efficiency of immunoassay cannot be balanced. Aiming at such problems, our team has carried out a series of research work, such as the precise preparation of mouse/rabbit monoclonal antibodies based on single B-cell, the rapid discovery and controllable screening of nanobodies, and the evolution of antibody affinity/stability. These studies are expected to provide core recognition materials for the development of next-generation rapid detection immunoassay technologies.

专家简介

Prof. Zhanhui Wang has received several honorary titles, including the leading talent in scientific and technological innovation of the National “Ten-thousand Talents Program” of China and National Outstanding Youth Grant supported by the National Scientific Foundation of China. He is the executive deputy director of Beijing Key Laboratory for Animal-derived Food Safety and deputy secretary-general of the Food Quality Safety Testing Instrument and Technology Application Branch of China Instrument and Control Society and the deputy director of the Chinese Preventive Medicine Association of Food Hygiene Branch. He acts as the executive director of Veterinary Pharmacology and Toxicology Branch of Chinese Association of Animal Science and Veterinary Medicine, the executive director of Veterinary Food Hygiene Branch of Chinese Association of Animal Science and Veterinary Medicine. He is a member of the Food and Drug Safety Expert Group of the Ministry of Science and Technology. Prof. Wang has devoted to the creation and preparation of biological materials for chemical compounds mainly in animal-derived foods, development of rapid methods and products, and antibody recognition mechanisms.

Prof. Zhanhui Wang has presided over more than 30 projects including the National Natural Science Foundation of China, the Thirteen’s Five-Year Plan of National Key Research and Development, and Key Research and Developmental Program of Beijing. Prof. Wang received Second Prize of National Technology Invention Awards in 2015; 2) First Prize China Agricultural Science and Technology Award in 2013. Prof. Wang has published over 150 peer review papers, including Anal Chem, J Agric Food Chem, Food Chem, Chinese Journal of Analytical Chemistry. Pro. Wang has more than 60 authorized national invention patents and more than 50 rapid detection products. He is also holding the post of journal editorial board member, guest editor in some journals, such as J Agric Food Chem, PLoS Comput Biol, Biomolecules, and Journal of Food Safety and Quality.

专家简介

Prof. Zou is the Head of the Department of Pharmaceutical Analysis at China Pharmaceutical University. From 2012 to 2020, he was working at the Department of Pharmacology, Jinling Hospital, Nanjing University School of Medicine as a Senior Research Fellow. From 2018 to 2019, he was working at Monash Institute of Pharmaceutical Sciences (MIPS), Monash University, Australia as a Visiting Scholar. In 2021, he moved to the School of Pharmacy, China Pharmaceutical University. His current work focuses on developing nucleic acids detection methods for point of care testing, and protein detection strategies for single cell analysis. He has published more than 50 papers in Angew Chem Int Ed, Nucleic Acids Res, Chem Sci, Genome Bio, Biosens Bioelectron and other journals. He is the recipient of Jiangsu Outstanding Youth Fund, Jiangsu "333 talents" and Jiangsu "six talents peak" talents.

专家简介

Prof. Xiao is currently a Professor at State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences. She has been long engaged in research of in-vitro diagnostic new technology, and developed a series of portable detection instruments. She has successively hosted or participated in more than 20 scientific research projects. She has published over 80 papers in Journals such as Biosensors and Bioelectronics, Chemical Engineering Journal, Journal of Hazardous Materials, Analytical chemistry and so on, which have been cited over 3000 times. Among the published papers, there are 5 papers selected as ESI Highly Cited Papers, entering the top 1% of their academic field. She holds more than 46 issued patents and 12 software copyrights. She won the National Defense Science and Technology Excellence Youth Fund in 2022.

报告摘要

The study of synthetic gene circuits is one of the cutting-edge research in the cross integration of biology and information technology, committed to designing and constructing new molecular circuits from the perspective of synthetic genes, achieving biological computing and programmable cellular intelligence. In the early stage of the research group, based on cyclic single stranded DNA (CssDNA) and DNA origami technology, information transmission and encrypted information storage of variable DNA structures were achieved, and controllable operations and molecular communication based on variable DNA structures were explored. However, the implementation of DNA molecular circuit modules in cells and animals still poses significant challenges. In the past two years, the research team has found that CssDNA can also serve as a gene expression vector and can be efficiently expressed in various cell lines. This enables the construction of stable, versatile, and highly reliable synthetic gene circuits, which can be applied in cutting-edge fields such as diagnosis, treatment, biological computing, and brain like intelligence.

专家简介

Jie Song is a researcher at the Hangzhou Institute of Medicine, Chinese Academy of Sciences, Professor at Shanghai Jiao Tong University, and a recipient of the National Overseas High Level Talent Youth Program (2016). He is also a recipient of the Outstanding Youth Fund of the Natural Science Foundation (2018). The main research directions of the research group are DNA nanotechnology and molecular communication and information storage, intelligent drug delivery systems and gene therapy, as well as the development and application of intelligent diagnostic and therapeutic instruments. The research group has published over 80 articles, including top international academic journals such as Science, Nature, Cell, Nature Nano, Nature Chemistry, Nature Communication, PNAS, JACS, etc. For details, please refer to the homepage: https://songresearchgroup.com/ .

报告摘要

The development of targeted molecules with excellent properties, such as high specificity and high affinity, is the basis of achieving biochemical measurement in vivo. Targeted peptides with endogenous activity possess high information content and biocompatibility. It is a kind of good specific recognition molecules. However, it is difficult to achieve the synergy in screening efficiency, screening accuracy and peptide properties conformation with conventional molecular screening and molecular evolution methods. A novel multi-dimensional molecular directed evolution method for targeted peptides based on microfluidic chips was proposed. The peptide molecules obtained by this method have the properties of specific recognition, stable assembly in vivo, and sequential regulation.

专家简介

Weizhi Wang, Professor of Beijing Institute of Technology, principal investigator. She received her bachelor's degree in applied chemistry from the Beijing Institute of Technology in 2006 and her doctorate degree from the Institute of Chemistry, Chinese Academy of Sciences in 2011. She worked at the The National Center for Nanoscience and Technology from 2011 to 2019. She joined the School of Chemistry and Chemical Engineering, Beijing Institute of Technology in 2019. Her research interests include microfluidic based high-content screening as well as recognition and analysis of peptides. In recent years, she has published more than 50 papers, such as Angew.Chem. Int. Ed., Adv.Mater., Anal. Chem. And ACS Nano. There are more than 10 authorized invention patents. She has won the second prize of China Association for Instrumental Analysis (CAIA) in 2020.

报告摘要

Dr. Li’s recent research effort was put on the discovery of novel protein post-translational modifications (PTMs), specifically stereochemical modification (SCM), empowered by signal amplification-based, conformer-resolved mass spectrometry technique. Unlike traditional PTMs, SCM does not change the mass or charge of the substrate proteins and peptides. Instead, only a few portions of the carbon centers of amino acid backbones was reversed spatially, usually from L-configuration to D-configuration. This no-mass change type of PTM has been linked to neurodegenerative disease including Alzheimer’s disease over ten years. However, the exact molecular mechanism behind this linkage is definitely poor understood, primarily due to the lack of high-resolution and sensitive tools to dissect the SCM from the proteome ocean at large scale. This fact inspires the major research direction of LimsLab, and Dr. Li has been recently funded by the National Key R&D Program of China for this specific project. In this talk, Dr. Li will introduce the recent progress of his team in this direction.

专家简介

Dr. Gongyu Li (Assistant Professor, Nankai University) obtained his Ph.D. degree in Analytical Chemistry under the supervision of Prof. Dr. Guangming Huang at University of Science and Technology of China (USTC) in June 2017. Dr. Li conducted his postdoc research at University of Wisconsin-Madison under the supervision of Prof. Dr. Lingjun Li from August 2017 to January 2021. In 2016 and 2019, he visited Dr. Brandon T. Ruotolo’s lab at University of Michigan as a visiting graduate student and visiting scholar, respectively, where he started and extended his ion mobility spectrometry research. After these professional preparations, he joined the College of Chemistry at Nankai University in February 2021 as a tenure-tracking Assistant Professor, where he was also one of the members of "Hundred Youth Academic Leader" of Nankai University.

At Nankai, Dr. Li established his own laboratory with the name of LimsLab -indicating the emphasis on MS research (Li-MS-Lab) and ion mobility spectrometry (Li-IMS-Lab), also the love of MS (in Chinese, “I” means love). The major research interest for LimsLab focuses on method development and innovative applications of conformer-resolved mass spectrometry, providing molecular basis and next-generation precise diagnosis and therapeutics for human neurodegenerative disease.

Gongyu has also been recognized as one of the five recipients (the only Chinese) for the highly competitive ASMS Postdoctoral Career Development Award in 2019. Dr. Li has been an active contributor in the field of biological mass spectrometry as evidenced by his frequently invited oral presentations at national and international conferences as well as serving as an invited reviewer for numerous peer-reviewed journals. To summary, Dr. Li has earned 8 national grants with over ￥12M in total, and 8 scientific publications as a corresponding author to date, including 1 Chem. Sci. and 3 Anal. Chem. papers, along with 700+ citations.

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