New Dynamic MRM Mode Improves Data Quality and Triple Quad Quantification in Complex Analyses
2022-11-04 09:13
浏览:10次
分享:
资料摘要:
Multiple Reaction Monitoring (MRM) mode has become the preferred method for the quantitative analysis of known or target compounds using triple quadrupole mass spectrometry.The current solution for MRM analysis uses time segmentation, where a method is divided into a series of time segments and predefined sets of MRM transitions are monitored for each segment. As sample complexity increases (e.g. quantifying very low levels of hundreds of pesticide residues in a wide variety of food matrices), very real practical limitations in the time-segmentation methodology become apparent. A better solution is required.
New dynamic MRM methods on the Agilent 6400 Series triple quad instruments create new capability to tackle large multi-analyte assays and to accurately quantify exceedingly narrow peaks from fast Agilent 1200 Series RRLC and 1290 Infinity UHPLC separations. Examples of pesticide analysis and rapid screening of drugs of abuse are highlighted. Dynamic MRM methods yield equivalent, or better, quality data and results as compared to traditional time segment based methods – plus easier method development and modification.
下载本篇资料:
NewDynamicMRMModeImproves.pdf
509KB
相关资料
药物发现和开发期间,需要可靠且易用的仪器进行化合物鉴定和纯度检查。Agilent 6120B 单四极杆硬件和软件是在多用户环境中支持 Walkup LC/MS 方法分析小分子和生物分子的理想选择。简洁的软件界面与稳定耐用的硬件结合,让非专家用户也可以自信地执行高质量且可靠的 LC/MS 分析。AgilentMassHunter Walkup 软件提供自动电子邮件报告,用户坐在办公桌旁就可以接收到条理清晰的结果。本应用简报讨论了 6120B 单四极杆 Walkup 系统的主要硬件和软件功能,以及包括化学品库分析等应用中的实际使用。
Agilent 1260 Infinity 纯化系统 — 无限卓越的回收率和纯度 (PDF)
Agilent 1260 Infinity 低流速液相色谱系统 — 无限卓越的毛细液相色谱和纳流液相色谱 (PDF)
Agilent 7697A 顶空进样器 (PDF)