重组人CD223蛋白|CD223/LAG3蛋白|重组人淋巴细胞活化基因3蛋白

产品编号: KMP2247

产品名称: Human CD223 Protein, His Tag, Avi Tag

中文名称: 重组人CD223蛋白

中文全称: 重组人淋巴细胞活化基因3蛋白

关键词: 淋巴细胞活化基因3, Lymphocyte activation gene 3 protein, LAG3, LAG-3, Protein FDC, CD223, Human CD233 Protein, His Tag, Avi Tag, Recombinant Protein, KMP2247

物种: Human

宿主: HEK293 Cells

规格: 50ug, 100ug, 200ug

纯化方式: Affinity purification

纯度: >95% as determined by SDS-PAGE

内毒素水平: <1.0 EU/ug determined by the LAL method

缓冲体系: PBS, pH7.4

Uniprot: P18627

SDS-PAGE: KMP2247 SDS-PAGE image1.png

功能: Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648).

Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity).

FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity).

Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity).

May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (By similarity).

Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8+ and CD4+ T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648).

Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (By similarity).

Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (By similarity).

Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear (PubMed:8647185).

产品背景: Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin(Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.

保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.

运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.

说明: This product is for research use only.

官网链接: https://www.kmdbioscience.cn/

参考文献: 1.J. Immunol. 184:6545-6551 (2010)

2.Eur. J. Immunol. 24:3216-3221 (1994)  

3.Eur. J. Immunol. 26:1180-1186 (1996)