SC-79

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抑制剂描述：

产品名称：SC-79

产品别名：见爱必信官网

英文别名：SC-79

靶点：Akt

CAS：305834-79-1

纯度：≥98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

SC-79 is an activator of Akt; binds to the pleckstrin homology domain of Akt.

溶解性：DMSO ：36.5 mg/mL (100 mM)

体外研究：

SC79 suppresses PHAKTM-GFP plasma membrane translocation, and enhances phosphorylation of all three Akt isoforms in HEK293, HeLa, HL60, NB4, and HsSulton (B cells) cells. SC79 reduces neuronal excitotoxicity and prevents stroke-induced neuronal death. SC79 restores proliferation of BRAT1 knockdown cells, and reduces the production of superoxide in mitochondria of MitoSox positive cells.

体内研究：In the permanent focal cerebral ischemia mouse model, SC79 (0.04 mg/g, i.p.) enables the cytosolic activation of Akt, and recapitulates the primary cellular function of Akt signaling, resulting in augmented neuronal survival.

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