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Notoginsenoside Ft1

供货周期: 一周
品牌: 爱必信
规格: 98%
货号: abs820926
CAS号: 155683-00-4
报价: ¥1008
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抑制剂描述:

产品名称:Notoginsenoside Ft1

产品别名:见爱必信官网

英文别名:Notoginsenoside Ft1

靶点:Triterpenoids

CAS:155683-00-4

纯度:98%

外观:见爱必信官网

保存方法:store at -20℃ for one year(Powder)

描述:Notoginsenoside Ft1 is a saponin isolated from Panax notoginseng; stimulator of angiogenesis.IC50 value:Target: angiogenesis stimulatorin vitro: Ft1 increases translocalization of hypoxia-inducible factor-1α (HIF-1α) from cytoplasm to nuclei, where it binds to the vascular endothelial growth factor (VEGF) promoter, increasing the expression of VEGF mRNA and the subsequent secretion of the growth factor. Ft1 induces the activation of PI3K/AKT and Raf/MEK/ERK signaling pathways . Among the saponins examined, Ft1 was the most potent procoagulant and induced dose-dependent platelet aggregation. Ft1 reduced plasma coagulation indexes, decreased tail bleeding time and increased thrombogenesis. Moreover, it potentiated ADP-induced platelet aggregation and increased cytosolic Ca(2+) accumulation, effects that were attenuated by clopidogrel. Ft1 binds to platelet P2Y12 receptors. The increase in intracellular Ca(2+) evoked by Ft1 in HEK293 cells overexpressing P2Y12 receptors could be blocked by ticagrelor . Ft1 caused endothelium-dependent relaxations, which were abolished by l-NAME (inhibitor of nitric oxide synthases) and ODQ (inhibitor of soluble guanylyl cyclase). Ft1 increased the cGMP level in rat mesenteric arteries. GR and ER? were present in the endothelial layer and their antagonism by RU486 and PHTPP, respectively, inhibited Ft1-induced endothelium-dependent relaxations and phosphorylations of eNOS, Akt and ERK1/2 . Ft1 showed the best inhibitory effect on cell proliferation of SH-SY5Y cells with IC50 of 45μM. Ft1 not only arrested the cell cycle at S, G2/M stages, but also promoted cell apoptosis. Ft1 up-regulated the protein expressions of cleaved caspase 3, phospho-p53, p21, and cyclin B1, but down-regulated that of Bcl-2. Moreover, Ft1 enhanced the phosphorylation of ERK1/2, JNK and p38 MAPK .in vivo: Ft1 promotes the formation of blood vessels in Matrigel plug and wound healing in mice .

溶解性:

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体内研究:

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  产品货号   产品名称   规格 价格 大包装及货期
  abs820926   Notoginsenoside Ft1   5mg   1008.00   立即咨询

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爱必信(上海)生物科技有限公司

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913101155665500522

成立日期

2010-12-13

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Notoginsenoside Ft1由爱必信(上海)生物科技有限公司为您提供,货号abs820926,规格:98%,CAS号:155683-00-4,如您想了解更多关于Notoginsenoside Ft1价格、Notoginsenoside Ft1结构式、批发、用途等信息,欢迎咨询。除供应Notoginsenoside Ft1外,还可为您提供胰蛋白酶-EDTA消化液(0.25%) 不含酚红、白色念球菌蛋白酶K兔多抗,HRP标记、胶原酶 Ⅳ型;蛋白水解酶等试剂,公司有专业的客户服务团队,是您值得信赖的合作伙伴,爱必信客户服务电话,售前、售后均可联系。
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