Cepharanthine

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抑制剂描述：

产品名称：Cepharanthine

产品别名：见爱必信官网

英文别名：Cepharanthine

靶点：Alkaloids

CAS：481-49-2

纯度：99.14 %

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Cepharanthine is a biscoclaurine alkaloid inhibiting tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppressing cytokine production.

溶解性：体外:
DMSO 100mg/mL(164.82mM)
Water <1mg/mL
Ethanol <1mg/mL

2%DMSO+30%PEG300+5%Tween80+ddH2O 5mg/mL

体外研究：

Treatment of SaOS2 cells with Cepharanthine (CEP) (2.5-20 μmol/L) inhibits the cell growth in a concentration- and time-dependent manner. CEP (10 μmol/L) caused cell cycle arrest at G(1) phase and induced apoptosis of SaOS2 cells. CEP (10 and 15 μmol/L) significantly decreases the expression of STAT3 in SaOS2 cells. Furthermore, CEP (5 and 10 μmol/L) significantly inhibits the expression of target genes of STAT3, including the anti-apoptotic gene Bcl-xL and the cell cycle regulators c-Myc and cyclin D1.

体内研究：In nude mouse xenografts of SaOS2 cells, Cepharanthine (CEP) (20 mg?kg(-1)?d(-1), ip for 19 d) significantly reduces the volume and weight of the tumor.

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