英文名称 Vitronectin
中文名称 玻璃粘连蛋白抗体
别 名 Vitronectin; Complement S Protein; Epibolin; S Protein; Serum Spreading Factor; V75; Vitronectin V10 subunit; VN; VNT; VTN; S-protein; Serum-spreading factor; V75; Vitronectin V10 subunit; VTNC_HUMAN.
玻璃粘连蛋白抗体
说 明 书 0.1ml 0.2ml
研究领域 心血管 免疫学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 9/52kDa
细胞定位 细胞外基质 分泌型蛋白
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Vitronectin
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
玻璃粘连蛋白抗体 产品介绍 background:
Vitronectin (also known as serum spreading factor, S protein of complement or epibolin) is one of the major multifunctional cell adhesive glycoproteins in mammalian plasma and serum. It is a monomeric acidic glycoprotein detected as a mixture of 75 kD and 65 kD polypeptides. Vitronectin binds to heparin, collagen, streptococci and variety of cultured cells. It also acts as an inhibitor of the complement cascade by binding to the C5b9 complex. Vitronectin promotes cell adhesion and spreading by binding through its cell attachment tripeptide Arg-Gly-Asp (RG-D), activity which is mediated by several different integrin receptors. Apart from the significance for identifying the molecule in the above situations, it also plays an important role in events such as embryonal development, deposition of vitronectin in a number of fibrotic disease states, carcinomas and metastases.
Function:
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (By similarity).
Subunit:
Monomer. Interacts with SERPINE1/PAI1 (By similarity).
Subcellular Location:
Secreted, extracellular space.
Tissue Specificity:
Plasma.
Post-translational modifications:
Sulfated on 2 tyrosine residues (By similarity).
N- and O-glycosylated (By similarity).
It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
Similarity:
Contains 4 hemopexin-like domains.
Contains 1 SMB (somatomedin-B) domain.
Gene ID:
7448
Database links:
Entrez Gene: 7448 Human
Entrez Gene: 22370 Mouse
Entrez Gene: 29169 Rat
Omim: 193190 Human
SwissProt: P04004 Human
SwissProt: P29788 Mouse
Unigene: 2257 Human
Unigene: 3667 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
玻璃粘连蛋白抗体
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