纤维母细胞生长因子3抗体

供货周期： 7天

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型号： 0.2ml/200μg

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报价： ¥1

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产品介绍

纤维母细胞生长因子3抗体英文名称 Anti-FGF3

中文名称纤维母细胞生长因子3抗体

别名 FGF 3; Oncogene INT2; Fibroblast growth factor 3; HBGF 3; HBGF3; INT 2; INT 2 proto oncogene protein; INT 2 proto oncogene protein precurosr; INT2; INT2 proto oncogene protein precurosr; Murine mammary tumor virus integration site (v int 2) oncogene homolog; Murine mammary tumor virus integration site 2; Oncogene INT2; V INT2 murine mammary tumor virus integration site oncogene homolog; FGF3_MOUSE.

浓度 1mg/1ml

规格 0.1ml/100μg 0.2ml/200μg

纯化的抗体可通过不同的途径获取，有些纤维母细胞生长因子3抗体可通过下述方法制备或从商家购买。从商家购买的抗体，通常附有正确的储存方法。

1）工作液应在4℃下融化并存放，可能稳定达数月。

2）如果没有特殊原因而避免使用叠氮钠，亦可加入叠氮钠，浓度为0．02％。将纯化的抗体样本分装成合适的体积，于-20℃保存。

3）纯化的抗体溶液应以较高的浓度(如lmg／m1)在中性pH下保存。：常用的抗体储存浓度高达l0mg/ml。较低浓度的抗体冻存前应浓缩。所有标准的浓缩方法(如超滤法)，皆可使用。还有一个简单的方法是用蛋白A或蛋白G亲和柱来浓缩溶液。如果纯化的抗体不是用于标记，可将它们以较低浓度储存于加有1％BSA的溶液中。

4）经纯化制备的抗体在常用的缓冲液中是稳定的。其DH应保持在中性左右。如果pH在7-8之间，即使保存多年，对抗体也无损害。多数情况下，盐浓度适于保持在0-150mmol/L之间，但在长期存放的抗体中，盐溶液浓度高达500mmol/L时，对纤维母细胞生长因子3抗体可能有损害。如果没有其他说明．律议用PBS或50mmol/LTris(DH8．0)溶液长期存放抗体。

抗体来源 Rabbit

克隆类型 polyclonal

交叉反应 Human, Mouse, Rat

产品类型一抗

研究领域肿瘤生长因子和激素

蛋白分子量 predicted molecular weight: 25kDa

性状 Lyophilized or Liquid

免疫原 KLH conjugated synthetic peptide derived from human FGF3 N-terminus

亚型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

纤维母细胞生长因子3抗体产品介绍 The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.

Function : Fibroblast growth factors (FGFs) can stimulate the proliferation of mesenchymal, epithelial and neuroectodermal cells. FGF3 belongs to the heparin binding growth factors family. Members of the family include Acidic FGF (also known as aFGF or FGF 1), basic FGF (bFGF or FGF 2), FGF 3 (also known as Int2) and FGF 4 (also known as hst or Kaposi FGF). FGF 4 was first revealed to be an oncoprotein in Kaposi's sarcoma cells. Other family members include FGF 5, FGF 6, FGF 7 (keratinocyte growth factor, KGF), FGF 8 (AIGF), FGF 9 (GAF) and FGF 10. FGF3 is activated by proviral insertion of mouse mammary tumor virus (MMTV). FGF3 is responsible for most of breast malignancies.

Subunit : Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).

Subcellular Location : Secreted.

Post-translational modifications : Glycosylated.

Similarity : Belongs to the heparin-binding growth factors family.

Database links : UniProtKB/Swiss-Prot: P05524.3

纤维母细胞生长因子3是FGF家族的成员。FGF家族参与一系列的生理功能：胚胎发育、细胞生长、器官形成、组织修复、肿瘤生长、侵袭等。FGF3/FGF4在很多恶性肿瘤中呈高表达，被视为原癌基因之一。