重组人α-突触核蛋白(Recombinant Human a-Synuclein)

Alpha Synuclein Human
Alpha Synuclein Human Recombinant
Catalog No. PRO-393

Synonyms:
Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, PD1, PARK1, PARK4, MGC110988, α-Synuclein, SNCA.

Introduction:
a-Synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. a-synuclein has been suggested to be implicated in the pathogenesis of Parkinson’s disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Moreover, recent studies have shown that a-synuclein has chaperone activity and that this activity is lost upon removing its C-terminal acidic tail (amino acids 96-140).

Description:
a-Synuclein Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain having a molecular mass of 14,460 Dalton.
The Recombinant Human a-Synuclein is purified by proprietary chromatographic techniques.

Source:
Escherichia Coli.

Physical Appearance:
Sterile filtered colorless solution.

Formulation:
The protein (1mg/ml) contains 20mM Tris-HCl buffer (pH 7.5), 0.1M NaCl and 1mM MgCl2.

Stability:
Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Other Recombinant forms available:
α-Synuclein A30P
α-Synuclein A53T
α-Synuclein A30P/A53T
α-Synuclein Delta-NAC
α-Synuclein 112(NACP112)
α-Synuclein 61-140
α-Synuclein 96-140
α-Synuclein 1-60
α-Synuclein E46K
α-Synuclein 1-95

Purity:
Greater than 95.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.

Sequence:
MDVFMKGLSK/ AKEGVVAAAE/ KTKQGVAEAA/ GKTKEGVLYV/
GSKTKEGVVH/GVATVAEKTK/
EQVTNVGGAV/VTGVTAVAQK/TVEGAGSIAA/ ATGFVKKDQL/
GKNEEGAPQE/ GILEDMPVDP/DNEAYEMPSE/EGYQDYEPEA.

Usage:
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

» Beta Synuclein Human
» Gamma Synuclein Human