Turbiscan AGS/多重光散射仪/稳定性分析仪

多重光散射仪在药物制剂中的应用

The world of drug delivery is getting every day more efficient with new product forms, which are directly targeting the deficient organs. Colloidal systems such as emulsions (simple or multiple) or nanoparticle suspensions are now widely used as drug carriers or nutritional solutions in this respect. These new product forms allow better targeting and assimilation for the patient, and give rise to new solutions for drug designers. However, the stability of these inherently unstable colloidal systems makes them complex to formulate and study.

多重光散射仪在石油领域中的应用

Asphaltenes are causing major problems in the extraction process of crude oil as they can lead to fouling & clogging in pipes or even in the entire well when they aggregate. Moreover asphaltenes play the role of natural emulsifier which stabilises water-in-oil emulsions formed during production of crude oil. Asphaltenes also have an impact on the refinery efficiency and the fuel oil quality. To overcome these technical issues, chemical additives are used. It is therefore important to have a technique that can identify the most suitable additive, but also to measure accurately the stability of oil or emulsions

多重光散射仪在食品/化妆品领域中的应用

介绍多重光散射仪/稳定性分析仪在食品化妆品行业中的应用概况，该仪器适用于研发、质量控制、工艺优化等阶段，可用于分析所有液态分散体系的物理不稳定现象。

Gelling of an emulsion

Gelling can be obtained through two main mechanisms: creation of a network due to a reticulation of polymers (it is the case for gelatin) or aggregation of particles (it is the case in yogurt). In the cosmetics industry it is commonly used to get various textures.

Shaving foam

Foams can be assimilated to gas in liquid emulsions. They are very unstable products and their life span does not exceed the few minutes of its application. In the case of shaving foams, the breaking of the product has to be sufficiently slow to enable a good protection of the skin during the shaving process. Therefore the kinetics of breaking is a fundamental parameter for the formulator. However, this characterization is very difficult to perform due to the fragility of the system. With using the Turbiscan LAb it is possible to study the kinetics of breaking of such products.

Release of an active encapsulated

Double emulsions are colloidal systems of great interest for the cosmetics industry as they enable to encapsulate both hydrophilic and lipophilic molecules. However, their formulation is very delicate and requires an important know-how. Their characterisation is also quite limited with classical techniques that, for most of them require dilution (particle size), or are not quantitative (microscopy). The Turbiscan Lab enables such characterization (see application note “Pre-formulation of a double emulsion”). The study of the kinetics of release of the active encapsulated in the internal emulsion is also very interesting for the formulator. However, here again, very few techniques are available.

Pre-formulation of a double emulsion

Double emulsions are colloidal systems of great interest for the cosmetics industry as they enable to encapsulate both hydrophilic and lipophilic molecules. However, their formulation is very delicate and requires an important know-how. Their characterisation is also quite limited with classical techniques that, for most of them require dilution (particle size), or are not quantitative (microscopy). The study of the kinetics of release of the active encapsulated in the internal emulsion is also very interesting for the formulator. However, here again, very few techniques are available apart from the Turbiscan Lab (see application note “Study of the release of an encapsulated active in a double emulsion”).

Hair foam

Foams can be assimilated to gas in liquid emulsions. They are very unstable products and their life span does not exceed the few minutes of its application. In the case of hair foams, the breaking of the product has to be quick to enable an easy application. Therefore the kinetics of breaking is a fundamental parameter for the formulator. However, this characterization is very difficult to perform due to the rapidity of the phenomenon. With using the Turbiscan LAb in the « fixed position » it is possible to study the kinetics of breaking of such products.

Hair foam

Foams can be assimilated to gas in liquid emulsions. They are very unstable products and their life span does not exceed the few minutes of its application. In the case of hair foams, the breaking of the product has to be quick to enable an easy application. Therefore the kinetics of breaking is a fundamental parameter for the formulator. However, this characterization is very difficult to perform due to the rapidity of the phenomenon. With using the Turbiscan LAb in the « fixed position » it is possible to study the kinetics of breaking of such products.

Hair foam

Foams can be assimilated to gas in liquid emulsions. They are very unstable products and their life span does not exceed the few minutes of its application. In the case of hair foams, the breaking of the product has to be quick to enable an easy application. Therefore the kinetics of breaking is a fundamental parameter for the formulator. However, this characterization is very difficult to perform due to the rapidity of the phenomenon. With using the Turbiscan LAb in the « fixed position » it is possible to study the kinetics of breaking of such products.

Formulation of a direct emulsion

Mixtures of surfactants are commonly used in the industry, as industrial surfactants are usually mixtures very difficult to purify. Moreover, a synergy between surfactants is very often observed, enabling to get an even better stability. Therefore, the formulator has to test a large range of surfactant mixtures. In order to make his choice quickly and in the best possible way, he needs an analytical tool to evaluate the stability of his formulations.

Flocculation by depletion

Emulsions are unstable colloidal systems that undergo many destabilisation phenomena (coalescence, flocculation, creaming, etc.) that can be due to various causes (lack of surfactant to cover the interface, attractive forces, etc.). Therefore, it is very important for the formulator to know the origins of these processes in order to be able to overcome them to get a stable product.

The Effect Of Ingredient Quality

The nature and the quality of a constituent in a formulation may have repercussions on its stability. The formulators need to test the stability of their emulsions, suspensions and foams with different types of raw materials.