A series of volatile organic compounds (VOCs) in drinking water are determined using In-Tube Extraction comprehensive GC/time-of-flight mass spectrometry (ITEX GCxGC/TOF-MS). A method for determining these compounds has been established and detection limits for a selected number of VOCs are depicted. Detection limits were below 20 ng/L for all compounds. A comparison with ‘classical’ Purge & Trap GC/MS is made. Repeatablility experiments revealed an RSD of less than 20% for all the compounds, well within the demands of the Flemish decree on drinking water

双臂多功能自动进样器+Optic 4多模式进样口安装成功 联和层析开发的方案双臂多功能自动进样器+Optic 4多模式进样口+冷聚焦装置顺利在上海某客户 布鲁克GCMS上安装成功。 联和层析工程师在该平台上为用户开发了自动化、客制化的解决方案，有效的帮助用户解决了实验 过程中碰到的难题。

主要特点 一套系统可实现在线SPE和自动进样功能，切换方便； 平台性，用户可选择系统优化好的SPE填料，也可自行选择其它填料SPE柱以应对不同的检测项目； 由自动进样器嵌入式系统而不是控制软件负责阀门切换，延时<100ms； 兼容Thermo、Waters、Agilent、Bruker等主流厂家的LC-MS/LC-MS-MS系统； 从SPE洗脱到LC柱时可自动补充水相，增加待测物在LC柱上保留性，增加溶剂选择的灵活性； 控制软件支持宏命令，可进行二次开发满足用户客制化的要求； 根据检测项目和SPE承载量不同，最大进样量可达20mL甚至更多； Load Ahead功能，上一个样品在进行LC-MS分析时，自动完成下一样品SPE柱的再生、上样、净化富集，最大程度的提高昂贵部件LC-MS/LC-MS-MS的利用率。

MonoTrapTM is a silica-based adsorptive. This product can be characterized by through pour (due to the monolith structure of the silica base) and a large surface (due to the pores within the silica frame). Active carbon is used as an adsorptive on the silica frame surface to which octadecyl (ODS) group has been conjugated. MonoTrapTM can be viewed as a new hybrid adsorptive having a large surface area and possessing the features of silica gel, active carbon and ODS group.

A series of volatile organic compounds (VOCs) in drinking water are determined using In-Tube Extraction comprehensive GC/time-of-flight mass spectrometry (ITEX GCxGC/TOF-MS). A method for determining these compounds has been established and detection limits for a selected number of VOCs are depicted. Detection limits were below 20 ng/L for all compounds. A comparison with ‘classical’ Purge & Trap GC/MS is made. Repeatablility experiments revealed an RSD of less than 20% for all the compounds, well within the demands of the Flemish decree on drinking water

Abstract 在生化分析LC-MS-MS中，影响电离过程的基质效应是主要因素，关系到分析结果的质量。一般这样的基质效应与生物体液本身的洁净程度有着直接关系。为了建立一个在充足清洁的MS程序用于现在体液中的的基本分析物（如尿液，血浆），这是基于固相萃取（SPE）原则，结合度身定造的固相萃取柱填料和自动柱切换开发。这种新型的多维（MD）固相萃取平台依赖于填充了允许分子尺寸限制通过材料（RAM）的反相色谱(SEC-RPC)固相萃取柱与填充了允许离子交换的混合型填料（MMP）的反相色谱(SEC-RPC)固相萃取柱相结合。为评估这MD-SPE平台，8个三环类抗抑郁药和两个代谢产物被选为模型组份。为了监测基质效应，比如离子抑制效应， 柱后输液实验演示，并与两维固相萃取柱模式（SEC-RPC）对比，表明MD-SPE平台可以更高效去除那些抑制电离延长的高、低分子量组份。此外，该模型组份的电喷雾并没有受到基质研究组份的相互之间或者内部的个别差异的影响。这亦是独立于物种体液原始形式。结果表明，MD-SPE平台有特殊的潜力向对于在线的SPE处理那些有一个pKa值 > 6.5和中等急性至低极性基本药物在不同的体液中。

A simple method is described for the determination of primary and secondary amines in foodstuffs by gas chromatography with a modified thermal energy analyser, operated in the nitrogen mode. Food samples were subjected to mineral oil vacuum distillation and the isolated amines were derivatized with benzenesulphonyl chloride to form the corresponding sulphonamides, which were fractionated to yield primary and secondary amine derivatives using a modified Hinsberg procedure. The detection limit for individual amines using a 10-g food sample was 10 micrograms/kg (ppb) and recoveries were in excess of 80%.

A gas chromatographic (GC) procedure is described for the determination of dibutylamine (DBA) in ham at less than 1 ppm. Sample is extracted with 0.5N HCl, centrifuged, made basic, and then extracted with isopropyl alcohol. Final determination is by GC/thermal energy analysis in the nitrogen mode. Six replicate analyses of ham fortified with 0.5 ppm DBA gave a recovery of 90.2 +/- 3.4%. Over a range of 0.5 to 3.0 ppm DBA, the repeatability was 0.07 ppm, and the coefficient of variation was 6.07%. Limit of detection was 0.1 ppm. Effectiveness of the procedure was demonstrated on selected ham samples.

A method is described for determining volatile nitrosamines in baby bottle rubber nipples and pacifiers. The method consists of overnight soaking of the sample with dichloromethane in the presence of propyl gallate, an inhibitor for artifactual formation of nitrosamines; extraction with dichloromethane using an ambient temperature column procedure; distillation from aqueous alkali; extraction of the aqueous distillate with dichloromethane and concentration of the extract using a Kuderna-Danish concentrator; and final analysis by gas chromatography with detection by thermal energy analyzer. Major improvements over other published methods include a simpler extraction, a more efficient distillation and concentration to minimize losses, and incorporation of propyl gallate inhibitor as well as of a test to detect unsuitable dichloromethane solvent that otherwise might lead to artifactual formation. The method is highly accurate (approximately 90% recovery) and precise (av. CV = 4.7% at greater than 9 ppb levels) and is applicable to determination of nitrosamines in both rubber- and plastic-based products.

A rapid method for the detection and quantification of N-nitrosodibutylamine (NDBA) migrating from rubber products into a neutral buffer solution is described. The extraction, clean up, and concentration is done by a one-step procedure using C18 cartridges. NDBA in the ppb range is identified and quantitated by gas chromatography (GC) with a thermal energy analyzer (TEA) as detector

本标准规定了用气相色谱-热能分析仪（GC-TEA）测定啤酒中挥发性N-亚硝胺的测定方法。 本标准适用于啤酒中N-亚硝基二甲胺含量的测定。 仪器的最低检出量为0.1 ng，在样品取样量为50 g，浓缩体积为0.5 mL，进样体积为10 μL时，本方法的最低检出浓度为0.1 μg/kg；在取样量为20 g，浓缩体积为1.0 mL，进样体积为5 μL时，本方法的最低检出浓度为1.0 μg/kg。

利用HS-SPDE/GC/MS/MS技术测定头发中毒品含量。A new method combination, headspace solid-phase dynamic extraction coupled with gas chromatography/ tandem mass spectrometry (HS-SPDE/GC/MS/MS), is introduced to determine drugs of abuse in hair samples. This highly automated procedure utilizes SPDE for pre-concentration and on-coating derivatization as well as GC and triple quadrupole MS/MS for selective and sensitive detection. All these steps, apart from washing and cutting of the hair samples, are performed without manual intervention on a robot-like autosampler. SPDE is a solventless extraction technique related to solid-phase microextraction (SPME). The analytes are absorbed from the sample headspace directly into a hollow needle with an internal coating of polydimethylsiloxane by repeated aspirate/dispense cycles. The HS-SPDE/GC/MS/MS procedure was applied to the analysis of methadone, the trimethylsilyl derivatives of cannabinoids and the trifluoroacetyl derivatives of amphetamines and designer drugs. The method was shown to be sensitive with detection limits between 6 and 52 pg/mg hair matrix and precision between 0.4 and 7.8% by the use of an internal standard technique. Linearity was obtained from 0.1–20 ng/mg with coefficients of correlation between 0.995 and 0.999. Compared with conventional methods of hair analysis, HS-SPDE/GC/MS/MS is easier to use, substantially faster, with the degree of sensitivity and reproducibility demanded in clinical and forensic toxicology. The main advantage of the SPDE technique in relation to SPME is the robustness of the capillary. Copyright # 2003 John Wiley & Sons, Ltd.