pION 药物渗透性检测仪

spm-raman

Introduction： The spatial resolution of Raman systems employing normal optical microscopes is limited to approximately the wavelength of the light (about 0.5 µm), because both the illuminating laser light and the Raman scattered light are collected in the optical far-field (i.e many wavelengths of light away from the scattering material). This resolution is sufficient for many users, but some need the higher resolutions attainable by scanning probe microscopies (SPM) such as atomic force microscopy (AFM) and near-field scanning optical microscopy (NSOM). This need can now be fulfilled by the combined Nanonics NSOM/AFM-100 Confocal™/Renishaw RM Series Raman microscope. Previously, investigating a sample with both scanning probe microscopy and Raman microscopy required moving the sample from instrument to instrument. The exact region being analyzed by the Raman microscope could not generally be found again for imaging with the chosen scanning probe microscopic technique. Direct correlation of a SPM technique with Raman scattering was a dream…now it is a reality.

GUT-BOX brochure

The Gut-Box is important accessory for your pION PAMPA system as it provides stirring and environmental stability for your assay during room temperature incubation. In conjunction with the Double-Sink™ protocol, PAMPA Evolution™ and PAMPA Explorer™ users can now perform assays in as little as 10 minutes.

Who is pION

美国Pion有限公司是药物ADME（吸收、分布、代谢和排泄）研究领域的领头军，其产品分布在全球各大知名制药公司研发部门和医药科研院所，旗下系列产品PAMPA(人造膜渗透性分析仪)是测试大量药物渗透性的最终平台，PAMPA的技术优势自1998年已经开始稳步增长，细胞培养的高成本和复杂性加速了全球药剂学公司采用PAMPA系统。它能提供用户样品制备、测试、数据分析和完整测试结果呈现的“交钥匙”系统；提供给没有全自动控制测试系统的用户一个试用版本。渗透性是麻醉药最大障碍之一，太高或太低都是问题。由于pH的不稳定，需要考虑其活性、被动吸收、还有亲油和亲水性，筛选大量的化合物细胞是至关重要的一步。利用人造的渗透性模板，操作简单，灵活和重复性好，大大加速了被动渗透性测量。

Pion－brochure

The ultimate platform for producing high-throughput permeability analysis.EVOLUTION provides a turnkey system for sample preparation and reading, data analysis, and presentation. For those not ready for full automation, there is the EXPLORER version.

Assessment of Transdermal Penetration Enhancement

Assessment of Transdermal Penetration Enhancement by Topical Pharmaceutical Excipients Using Skin PAMPA Method

Dissolution Permeability Apparatus

Dissolution Permeability Apparatus with Integrated In Situ Concentration Monitoriring of both Donor and Receiver Compartments

Novel HT Method for Parallel Excipient

Novel HT Method for Parallel Excipient/Vehicle Formulation Studies

Using Skin PAMPA for Transdermal Patch Testing

Using Skin-----PAMPA for Transdermal Patch Testing

Application of Skin PAMPA to differentiate between Topical Pharmaceutical Formulations of Ibuprofen

Application of Skin PAMPA to differentiate between Topical Pharmaceutical Formulations of Ibuprofen