结合紫外和电雾式检测器亲水作用色谱分析美托洛尔及选定的杂质组分
Key Words
Vanquish UHPLC System, Metoprolol, Metoprolol EP Impurity A, Metoprolol EP Impurity M, Metoprolol EP Impurity N, Corona Charged Aerosol Detector
Goal
To develop an impurity profiling method for metoprolol and EP impurity A, which contain chromophores and two non-chromophoric impurities, using a hydrophilic interaction chromatography (HILIC) method coupled with charged aerosol detection (CAD).