半胱胺酸蛋白酶-10抗体
2015-02-02 08:35
浏览:40次
分享:
资料摘要:
半胱胺酸蛋白酶-10抗体
Background: Caspases are a family of intracellular proteases that mediate cell death and are the principal effectors of apoptosis. Caspase 10 (Mch4, ICE-LAP4, FLICE2) plays an important role in apoptosis induced by a variety of inducers such as TNF alpha and Anti-Fas antibody. It is a large prodomain caspase classified together with caspases 2, 8, and 9 as a signaling caspase. Four isoforms of caspase 10 (caspase 10a, 10b, 10c, and 10d) having the same prodomain but different mature large and small subdomain, have been described. Caspase 10 contains two death domains (DED) involved in linking to the death effector domain of the adapter protein FADD and recruiting the complex to TNFR1 and Fas. The inactive procaspase 10 is variably expressed in many tissues and cell lines as a cytosolic protein. The mature form of caspase 10 comprises two subunits, p23/p17 (splice isoforms) and p12. Interestingly, a caspase 9- dependent processing of caspase 10 by caspase 6 in cell-free extracts has recently been suggested. Caspase 10 can cleave and activate caspases 3, 4, 6, 7, 8, and 9. This is followed by cleavage of numerous key proteins, including the nuclear protein PARP. Also known as: ALPS 2; ALPS2; Apoptosis related cysteine peptidase; Apoptotic protease Mch 4; CASP 10; CASP10; CASP10 protein; Caspase 10 apoptosis related cysteine peptidase; Caspase 10 apoptosis related cysteine protease; Caspase10; FADD Like Ice 2; Fas Associated Death Domain Protein; FAS associated death domain protein interleukin 1B converting enzyme 2; FLICE 2; FLICE2; ICE Like Apoptotic Protease 4; Interleukin 1B Converting Enzyme 2; MCH 4; MCH4.半胱胺酸蛋白酶-10抗体
推荐资料
大鼠胰岛素(INS)酶联免疫分析试剂盒用于测定大鼠血清,血浆及相关液体样本中胰岛素(INS)含量。本试剂盒仅供研究使用。
大鼠血管内皮生长因子 (VEGF)酶联免疫分析试剂盒用于测定大鼠血清,血浆及相关液体样本中血管内皮生长因子 (VEGF)含量。
大鼠胸肾表达趋化因子(BRAK/CXCL14)酶联免疫分析试剂盒用于测定大鼠血清、血浆及相关液体样本中胸肾表达趋化因子(BRAK/CXCL14)含量。
大鼠纤维蛋白原(FG)酶联免疫分析试剂盒用于测定大鼠血清血浆及相关液体样本中纤维蛋白原(FG)含量。