CD161抗体

英文名称    CD161    

中文名称    CD161抗体    

别    名    CD161 antigen like family member C; CD161 antigen-like family member C; CD161c; Killer cell lectin like receptor subfamily A member 1C; Killer cell lectin like receptor subfamily B member 1C; Klrb1c; Ly55c; Lymphocyte antigen 55c; Ly59; Lymphocyte antigen 59; Natural killer cell surface protein P1 40; Natural killer cell surface protein P1-40; Ly-55c; NK1.1 alloantigen; NKR P1.9; NKR P1C; NKRP1 40; NKRP1; NKRP1.9; Nkrp1-c; NKRP1C; NK-1.1; Nk-1.2; NK-RP1; NK1.1; NKR-P1; Nkrp1c; NKR-P1.9; NKR-P1C; KLRB1_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  免疫学  信号转导  细胞膜受体      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 CD161抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    25kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human CD161/NK11    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

CD161抗体产品介绍    background:

NK1.1, a member of the NKRPI family of cell surface receptors, is a type II integral membrane protein with a C type lectin domain. It is expressed as a disulfide linked homodimer on all NK cells, as well as subsets of thymocytes and peripheral T lymphocytes in selected strains of mice (e.g., C57/BL6, FVB/N, NZB; but not A, AKR, BALB/c, CBA/J, C3H, C57BR, C58, DBA/1, DBA/2, SJL, 129). NK1.1 mediates cellular activation and differentiation, and is thought to have a particular role in generating Th2 cells. 

Function:
Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.    

CD161抗体

hz-0583R c-Abl/Abl1  非受体酪氨酸激酶c-Abl抗体

hz-4083R phospho-c-Abl(Tyr134)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-3032R phospho-c-Abl(Tyr412)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-3041R phospho-c-Abl(Tyr245)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-3042R phospho-c-Abl(Tyr204)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-3044R phospho-c-Abl(Ser735)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-3071R phospho-c-Abl(Tyr89)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-4084R phospho-c-Abl(Tyr251)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-4085R phospho-c-Abl(Tyr272)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-4086R phospho-c-Abl(Tyr276)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-4087R SPTLC1  丝氨酸棕榈酰转移酶1抗体

hz-4088R SLC27A5  脂肪酸转运蛋白5抗体

hz-2932R Clathrin heavy chain/Clathrin HC  网格蛋白重链抗体

hz-2933R RAB-14  RAS相关蛋白癌基因Rab14抗体

hz-2936R ARHG7  p21活化蛋白激酶ARHG7抗体

hz-2938R TdT/DNTT  末端脱氧核苷酸转移酶抗体

hz-5183R phospho-c-Abl(Thr754)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-2940R FUCA1/Alpha L fucosidase I  α-L岩藻糖苷酶抗体

hz-2941R TNFR1/TNF Receptor I  肿瘤坏死因子受体1抗体

hz-2942R HHV8/ORF K14  人类疱疹病毒8 ORF14抗体

hz-2943R ShzA6D  轴突导向因子ShzA6D抗体

hz-2944R plant lectin B4/IB4  植物凝集素IB4

hz-2945R SNX1/Sorting nexin1  分选连接蛋白1抗体

hz-2947R ERG25  甲基固醇羟化酶单加氧酶1抗体

hz-5184R phospho-c-Abl(Tyr283)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-2950R Cytosine deaminase  胞嘧啶脱氨酶抗体

hz-2951R SQSTM1/p62  泛素结合蛋白P62抗体

hz-2952R NFAT4  核因子活化T细胞胞浆蛋白3抗体

hz-2953R Exportin 1/CRM1  染色体区域稳定蛋白/核输出蛋白1/染色体区域稳定必需蛋白抗体

hz-2954R IKZF3  锌指蛋白Aiolos抗体

hz-2955R C3a Receptor/C3aR  过敏毒素C3受体/补体C3受体抗体