英文名称 CD161
中文名称 CD161抗体
别 名 CD161 antigen like family member C; CD161 antigen-like family member C; CD161c; Killer cell lectin like receptor subfamily A member 1C; Killer cell lectin like receptor subfamily B member 1C; Klrb1c; Ly55c; Lymphocyte antigen 55c; Ly59; Lymphocyte antigen 59; Natural killer cell surface protein P1 40; Natural killer cell surface protein P1-40; Ly-55c; NK1.1 alloantigen; NKR P1.9; NKR P1C; NKRP1 40; NKRP1; NKRP1.9; Nkrp1-c; NKRP1C; NK-1.1; Nk-1.2; NK-RP1; NK1.1; NKR-P1; Nkrp1c; NKR-P1.9; NKR-P1C; KLRB1_HUMAN.
说 明 书 0.1ml 0.2ml
研究领域 肿瘤 免疫学 信号转导 细胞膜受体
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 CD161抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25kDa
细胞定位 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD161/NK11
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CD161抗体产品介绍 background:
NK1.1, a member of the NKRPI family of cell surface receptors, is a type II integral membrane protein with a C type lectin domain. It is expressed as a disulfide linked homodimer on all NK cells, as well as subsets of thymocytes and peripheral T lymphocytes in selected strains of mice (e.g., C57/BL6, FVB/N, NZB; but not A, AKR, BALB/c, CBA/J, C3H, C57BR, C58, DBA/1, DBA/2, SJL, 129). NK1.1 mediates cellular activation and differentiation, and is thought to have a particular role in generating Th2 cells.
Function:
Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
CD161抗体
hz-0583R c-Abl/Abl1 非受体酪氨酸激酶c-Abl抗体
hz-4083R phospho-c-Abl(Tyr134) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-3032R phospho-c-Abl(Tyr412) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-3041R phospho-c-Abl(Tyr245) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-3042R phospho-c-Abl(Tyr204) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-3044R phospho-c-Abl(Ser735) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-3071R phospho-c-Abl(Tyr89) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-4084R phospho-c-Abl(Tyr251) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-4085R phospho-c-Abl(Tyr272) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-4086R phospho-c-Abl(Tyr276) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-4087R SPTLC1 丝氨酸棕榈酰转移酶1抗体
hz-4088R SLC27A5 脂肪酸转运蛋白5抗体
hz-2932R Clathrin heavy chain/Clathrin HC 网格蛋白重链抗体
hz-2933R RAB-14 RAS相关蛋白癌基因Rab14抗体
hz-2936R ARHG7 p21活化蛋白激酶ARHG7抗体
hz-2938R TdT/DNTT 末端脱氧核苷酸转移酶抗体
hz-5183R phospho-c-Abl(Thr754) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-2940R FUCA1/Alpha L fucosidase I α-L岩藻糖苷酶抗体
hz-2941R TNFR1/TNF Receptor I 肿瘤坏死因子受体1抗体
hz-2942R HHV8/ORF K14 人类疱疹病毒8 ORF14抗体
hz-2943R ShzA6D 轴突导向因子ShzA6D抗体
hz-2944R plant lectin B4/IB4 植物凝集素IB4
hz-2945R SNX1/Sorting nexin1 分选连接蛋白1抗体
hz-2947R ERG25 甲基固醇羟化酶单加氧酶1抗体
hz-5184R phospho-c-Abl(Tyr283) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-2950R Cytosine deaminase 胞嘧啶脱氨酶抗体
hz-2951R SQSTM1/p62 泛素结合蛋白P62抗体
hz-2952R NFAT4 核因子活化T细胞胞浆蛋白3抗体
hz-2953R Exportin 1/CRM1 染色体区域稳定蛋白/核输出蛋白1/染色体区域稳定必需蛋白抗体
hz-2954R IKZF3 锌指蛋白Aiolos抗体
hz-2955R C3a Receptor/C3aR 过敏毒素C3受体/补体C3受体抗体
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