智能中试涂布机

Talk.科循 智能中试涂布机—国产替代的明智之选

透皮制剂研发的热潮催生了涂布机市场，目前高端的中试涂布机、生产型涂布机仍然是以高价的欧美、日本品牌为主，而随着国产替代的时代来临，科翔科技在透皮吸收实验室技术和设备的优势逐步被市场认可，其高性价比的智能中试涂布机逐渐的在高端市场占据一席之地，纷纷落户恒瑞制药、九典制药、新领先、红珊瑚….等制药企业。

Pharmacokinetics and pharmacodynamics of glycyrrhetinic acid with Paeoniflorin after transdermal administration in dysmenorrhea model mice

Background: Glycyrrhetinic acid (GA) and paeoniflorin (PF) are the main active ingredients in Chinese peony- Liquorice Decoction, a widely used Traditional Chinese Medicine. Hypothesis/Purpose: The aim of this work was to investigate the combinatory analgesic effect of GA and PF after percutaneous administration and to define their pharmacokinetic/pharmacodynamic (PK/PD) characteristics. Study design and Methods: GA and PF were produced to transdermal patches based on previous research, and the permeation parameters of GA and PF in the patches were investigated with in vitro experiments. Dysmenorrhea model mice were then produced to compare the analgesic effects of the patches with different proportions of GA-PF. In the in vivo assessment, the number of writhes exhibited by the dysmenorrhea mice was recorded at designated time points, and skin, muscle under skin and plasma samples were collected, for assessments of drug distribution, pharmacokinetics parameters and PK/PD characteristics. Results and conclusion: In dysmenorrhea mice, GA-PF and meloxicam (the positive control drug) could relieve pain to equal degrees. Specifically, a single dose of the optimized patches (10%GA-10%PF, wt) exerted a steady analgesic effect for 48 h in dysmenorrhea mice, but this effect lagged behind the changes in the plasma concentration. Evaluation with the Bliss Independence criterion revealed that the two ingredients displayed a synergistic effect. Then the PK/PD relationship of GA in this compound preparation was defined with this synergistic effect. The preparation might be suitable for topical spasmolysis and anti-inflammatory therapy

适用于经皮给药系统的SIS-g-NPEO热熔压敏胶 及其释药性研究

通过原位环氧化反应与开环接枝反应相结合，将亲水性壬基酚聚氧乙烯醚（ ） 支链引入聚苯乙烯-异戊二烯-苯乙烯（ ）三嵌段共聚物，制备功能型 热塑弹性 S I S S I S - g - N P E O 体，并以S I S - g - N P E O为骨架，配以增粘树脂、矿物油、氢化松香树脂、抗氧剂等组分，制备了 面向经皮给药系统的S I S - g - N P E O热熔压敏胶，以栀子苷为亲水性模型药物，研究S I S - g - N P E O热 熔压敏胶中各组分对栀子苷的释放影响。结果显示， 树脂和增塑剂 有利于栀子苷释放；矿 C 5 P E G 物油不利于亲水性成分栀子苷的释放。