冈田酸(PP1和PP2A抑制剂)
Okadaic acid
产品规格: 5ug/50ul (Ethanol)
CAS: 155751-72-7
保存条件: Store at -20℃ stable for 24 months.
产品介绍:
基本信息:
CAS:155751-72-7
分子式:C44H67KO13
分子量:843.09
MDL:MFCD00214356
纯度:≥90% (HPLC), powder
溶解性:溶于乙醇(5 ug/50 ul = 124.2 μM)
产品简介:
冈田酸 (Okadaic acid) 是一种海洋毒素,是蛋白质磷酸酶 (PP) 的抑制剂,包括 PP1 (IC50=15-50 nM)、PP2A (IC50=0.1-0.3 nM)、PP3 (IC50=3.7-4 nM)、PP4 (IC50=0.1 nM) 和 PP5 (IC50=3.5 nM),其中对 PP2A 的亲和力最显著,但不抑制 PP2C。Okadaic acid 通过抑制 PP 增加了多种蛋白的磷酸化,并具有肿瘤启动子的作用。Okadaic acid 诱导 tau 蛋白磷酸化。
作用靶点:Phosphatase; Apoptosis;
作用通路:Metabolic Enzyme/Protease; Apoptosis
体外研究:
Okadaic acid (0-100 nM; 24 h or 48 h) inhibits the proliferation of AGS, MNK-45, Caco 2 cells[3].
Okadaic acid (10 nM; 8 hours) increases Drp1 phosphorylation and mitochondrial fission in rat cortical neurons[4].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay[3]
体内研究:
Okadaic acid (100 μM; injected unilaterally to the lateral amygdala) induces Tau phosphorylation and protein aggregation in anatomically distinct brain regions 24 h post-injection[5]
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