公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! 产品描述: 产品名称:Recombinant Human NEDD8-Conjugating Enzyme UBC12/UBE2M 描述: Recombinant Human Ubiquitin-conjugating Enzyme E2M is produced by our E.coli expression system and the target gene encoding Met1-Lys183 is expressed. 氨基酸序列: MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDINELNLPKTCDISFSDPDDLLNFKLVIC PDEGFYKSGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDWKPVLTINSIIY GLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQRSMRGGYIGSTYFERCLK 背景说明: UBE2M is a member of the E2 ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. UBE2M accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. It involved in cell proliferation and is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. 别名: NEDD8-conjugating enzyme Ubc12, NEDD8 carrier protein, NEDD8 protein ligase, Ubiquitin-conjugating enzyme E2 M, UBC12, UBE2M, Accession: P61081 纯度: Greater than 95% as determined by reducing SDS-PAGE. 来源: Escherichia coli. 内毒素水平: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test. 形态: Supplied as a 0.2 μm filtered solution of 50mM HEPES,pH 7.5,2mM DTT,150mM NaCl,10%glycerol . 产品信息订购:
产品货号 |
产品名称 |
规格 |
价格 |
大包装及货期 |
abs04422 |
Recombinant Human NEDD8-Conjugating Enzyme UBC12/UBE2M |
10ug |
252.00 |
立即咨询 |
abs04422 |
Recombinant Human NEDD8-Conjugating Enzyme UBC12/UBE2M |
50ug |
756.00 |
立即咨询 |
abs04422 |
Recombinant Human NEDD8-Conjugating Enzyme UBC12/UBE2M |
500ug |
5040.00 |
立即咨询 |
abs04422 |
Recombinant Human NEDD8-Conjugating Enzyme UBC12/UBE2M |
1mg |
7600.00 |
立即咨询 |
产品更多信息请进入爱必信网站咨询
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