GSK'547

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

抑制剂描述：

产品名称：GSK'547

产品别名：见爱必信官网

英文别名：GSK'547

靶点：RIP Kinase

CAS：2226735-55-1

纯度：98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）

描述：GSK547, a highly selective and potent RIP1 inhibitor, inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.

溶解性：

体外研究：

GSK547 (0.1-100000 nM; 24 hours) pretreats L929 cells with recombinant TNFα and zVAD at various doses for 30 min, then cell death is induced with an IC50 of 32 nM after 24 hours.GSK547 up-regulates STAT1 signaling in bone marrow-derived macrophages (BMDM).Cell Viability AssayCell Line:L929 cells (Mouse L-cells NCTC 929)Concentration:0.1 nM; 10 nM; 1000 nM; 100000 nMIncubation Time:24 hoursResult:Reduced viability of L929 cells after co-treatment with TNFα and zVAD with an IC50 of 32 nM.

体内研究：GSK547 (0.1-100000 nM; 24 hours) pretreats L929 cells with recombinant TNFα and zVAD at various doses for 30 min, then cell death is induced with an IC50 of 32 nM after 24 hours.GSK547 up-regulates STAT1 signaling in bone marrow-derived macrophages (BMDM).Cell Viability AssayCell Line:L929 cells (Mouse L-cells NCTC 929)Concentration:0.1 nM; 10 nM; 1000 nM; 100000 nMIncubation Time:24 hoursResult:Reduced viability of L929 cells after co-treatment with TNFα and zVAD with an IC50 of 32 nM.

产品信息订购：

产品更多信息请进入爱必信网站咨询