AVE-8134

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

抑制剂描述：

产品名称：AVE-8134

产品别名：见爱必信官网

英文别名：AVE-8134

靶点：PPAR

CAS：304025-09-0

纯度：

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）

描述：AVE-8134 is a potent PPARα agonist, with EC50 values of 100 and 3000 nM for human and rodent PPARα receptor, respectively.

溶解性：DMSO*

体外研究：

AVE8134 is a full PPARα dominated PPAR agonist, but not active on PPARδ. In HUVEC, AVE8134 (1 μM) increases Ser-1177-eNOS phosphorylation but not eNOS expression. In monocytes, AVE8134 (10 μM) increases the expression of CD36 and the macrophage scavenger receptor 1, resulting in enhanced uptake of oxidized LDL.

体内研究：AVE8134 is a full PPARα dominated PPAR agonist, but not active on PPARδ. In HUVEC, AVE8134 (1 μM) increases Ser-1177-eNOS phosphorylation but not eNOS expression. In monocytes, AVE8134 (10 μM) increases the expression of CD36 and the macrophage scavenger receptor 1, resulting in enhanced uptake of oxidized LDL.

产品信息订购：

产品更多信息请进入爱必信网站咨询