Elafibranor

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抑制剂描述：

产品名称：Elafibranor

产品别名：见爱必信官网

英文别名：Elafibranor

靶点：PPAR

CAS：923978-27-2

纯度：

外观：见爱必信官网

保存方法：

描述：Elafibranor is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively.

溶解性：DMSO: ≥ 33 mg/mL

体外研究：

GFT505 is a novel PPAR modulator that shows a preferential activity on PPAR-α and concomitant activity on PPAR-δ.

体内研究：Elafibranor (GFT505) is a dual PPARα/δ agonist that has demonstrated efficacy in disease models of nonalcoholic fatty liver disease (NAFLD)/NASH and liver fibrosis. In the rat, GFT505 concentrated in the liver with limited extrahepatic exposure and underwent extensive enterohepatic cycling. Elafibranor confers liver protection by acting on several pathways involved in NASH pathogenesis, reducing steatosis, inflammation, and fibrosis. GFT505 improved liver dysfunction markers, decreased hepatic lipid accumulation, and inhibited proinflammatory (interleukin-1 beta, tumor necrosis factor alpha, and F4/80) and profibrotic (transforming growth factor beta, tissue inhibitor of metalloproteinase 2, collagen type I, alpha 1, and collagen type I, alpha 2) gene expression.

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