PE859

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抑制剂描述：

产品名称：PE859

产品别名：见爱必信官网

英文别名：PE859

靶点：Amyloid-β

CAS：1402727-29-0

纯度：98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）

描述：

PE859 is a potent inhibitor of both tau and Aβ aggregation with IC50 values of 0.66 and 1.2 μM, respectively.

溶解性：DMSO : 50 mg/mL (111.48 mM; Need ultrasonic)

体外研究：

PE859 inhibits the heparin-induced aggregation of both 3RMBD and full length tau in a concentration-dependent manner. In each assay, the IC50 values calculated at the last measurement periods are 0.81 μM, and 2.23 μM, respectively. PE859 inhibits tau aggregation through formation of beta-sheet structure.

体内研究：PE859 inhibits the heparin-induced aggregation of both 3RMBD and full length tau in a concentration-dependent manner. In each assay, the IC50 values calculated at the last measurement periods are 0.81 μM, and 2.23 μM, respectively. PE859 inhibits tau aggregation through formation of beta-sheet structure.

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