PCI 29732

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抑制剂描述：

产品名称：PCI 29732

产品别名：见爱必信官网

英文别名：PCI 29732

靶点：BTK

CAS：330786-25-9

纯度：

外观：见爱必信官网

保存方法：

描述：PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.IC50 value: 8.2 nM [1]Target: Btk kinasePCI 29732(compound 1) has a 8.2 nM potency against Btk in a FRET based biochemical enzymology assay. PCI 29732 shows only modest inhibitory activity against Itk, another Tec family kinase, probably due to the difference at the “gatekeeper” residue [1].In human CD20+ B cells stimulated at the BCR, PCI-29732 blocked the transcriptional up-regulation of a panel of B-cell activation genes that occurs within 6 h of stimulation. Pulse exposure to the reversible inhibitor PCI-29732 did not result in BCR inhibition [2].

溶解性：DMSO: ≥ 53 mg/mL

体外研究：

体内研究：

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