N-Arachidonyl maleimide

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

抑制剂描述：

产品名称：N-Arachidonyl maleimide

产品别名：见爱必信官网

英文别名：N-Arachidonyl maleimide

靶点：Others

CAS：876305-42-9

纯度：≥98%

外观：见爱必信官网

保存方法：Store at -20°C

描述：

溶解性：Soluble in DMSO (~30 mg/ml), 100% ethanol (20 mg/ml), DMF (~30 mg/ml), and aqueous buffers (sparingly).

体外研究：

Previous study found that N-arachidonyl maleimide could increase the endogenous levels of 2-AG. Moreover, in agonist-stimulated guanosine 5'-O-(3-[(35)S]thio)triphosphate binding assay, N-arachidonyl maleimide was able to raise the potency of 2-AG, but not anandamide (AEA). In addition, unmasking of 2-AG effects of N-arachidonyl maleimide that were only partially reversed by SR141716A gave further support for the existence of non-CB(1), non-CB(2) cannabinoid receptors .

体内研究：Animal study showed that N-arachidonyl maleimide could unmask 2-AG activity in a tetrad of in vivo tests sensitive to the effects of cannabinoids in mice. The efficacy of 2-AG to produce hypothermia was reduced by the treatment of N-arachidonyl maleimide compared with Delta(9)-tetrahydrocannabinol. All tetrad effects were partially CB(1) receptor-mediated because they could be attenuated by CB(1) antagonist SR141716A and in CB(1)(-/-) mice .

产品信息订购：

产品更多信息请进入爱必信网站咨询