JI051

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抑制剂描述：

产品名称：JI051

产品别名：见爱必信官网

英文别名：JI051

靶点：Notch

CAS：2234281-75-3

纯度：

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）

描述：JI051 is a stabilizer for the Hes1-PHB2 interaction, interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene HesAnti-cancer activity.

溶解性：

体外研究：

JI051 causes G2/M cell-cycle arrest.JI051 (0.1-10 μM, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC50 of 0.3 μM.Cell Proliferation AssayCell Line:HEK293 cellsConcentration:0.1-10 μMIncubation Time:24 hoursResult:Dose-dependently inhibits the proliferation of HEK293 cells at low concentrations.

体内研究：JI051 causes G2/M cell-cycle arrest.JI051 (0.1-10 μM, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC50 of 0.3 μM.Cell Proliferation AssayCell Line:HEK293 cellsConcentration:0.1-10 μMIncubation Time:24 hoursResult:Dose-dependently inhibits the proliferation of HEK293 cells at low concentrations.

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