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抑制剂描述: 产品名称:Tiplaxtinin(PAI-039) 产品别名:见爱必信官网 英文别名:Tiplaxtinin(PAI-039) 靶点:PAI-1 CAS:393105-53-8 纯度:>98% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述:Inhibitor of plasminogen activator inhibitor-1 (PAI-1) 溶解性:DMSO 72 mg/mL (163.86 mM) 体外研究: In a panel of human bladder cell lines, PAI-1 results in the reduction of cellular proliferation, cell adhesion, and colony formation, and the induction of apoptosis and anoikis. 体内研究:In a rat carotid thrombosis model, Tiplaxtinin (1 mg/kg, p.o.) increases time to occlusion and prevents the carotid blood flow reduction. In C57BL/6J mice, (1 mg/g chow) attenuates Ang II-induced aortic remodeling. In untreated type 1 diabetic mice, Tiplaxtinin (p.o.) restores skeletal muscle regeneration. In athymic mice bearing human cancer cell line T24 and HeLa xenografts, Tiplaxtinin (1 mg/kg, p.o.) reduces tumor xenograft growth, associated with a reduction in tumor angiogenesis, a reduction in cellular proliferation, and an increase in apoptosis.
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企业名称
爱必信(上海)生物科技有限公司
企业信息已认证
企业类型
信用代码
913101155665500522
成立日期
2010-12-13
注册资本
2500
经营范围
爱必信(上海) 生物科技有限公司
公司地址
上海市浦东新区新浩路58号18号楼
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