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抑制剂描述: 产品名称:SU9516 产品别名:见爱必信官网 英文别名:SU9516 靶点:CDK CAS:377090-84-1 纯度:98% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述: SU 9516 is a 3-substituted indolinone CDK inhibitor with IC50 of 22 nM, 40 nM, and 200 nM for CDK2, CDK1, and CDK4, respectively. 溶解性:DMSO : 24.1 mg/mL (100 mM) 体外研究: SU9516 decreases cdk2-specific phosphorylation of the retinoblastoma protein pRB, increases caspase-3 activation, and alters cell cycle in RKO and SW480 cells. SU9516 also inhibits the cell proliferation, and induces cell apoptosis in both cell lines. SU9516 kills leukemic cells through inhibition of RNA Pol II CTD phosphorylation, oxidative damage and transcriptional down-regulation of Mcl-1. In human T-cell leukemia Jurkat cells, SU9516 significantly enhances sensitivity to methotrexate. In addition, SU9516 also suppresses Aurora-A centrosomal localization and consequent centrosome amplification. 体内研究:
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企业名称
爱必信(上海)生物科技有限公司
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信用代码
913101155665500522
成立日期
2010-12-13
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2500
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爱必信(上海) 生物科技有限公司
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上海市浦东新区新浩路58号18号楼
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